Sh3pxd2b SH3 and PX domains 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3pxd2bprovided by RGD
Official Full Name: SH3 and PX domains 2Bprovided by RGD
Primary source: RGD:1309926
See related: EnsemblRapid:ENSRNOG00000004063 AllianceGenome:RGD:1309926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309926
Summary: Predicted to enable SH2 domain binding activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in several processes, including osteoblast fate commitment; podosome assembly; and skeletal system development. Predicted to be located in cytoplasm and podosome. Human ortholog(s) of this gene implicated in Frank-Ter Haar syndrome. Orthologous to human SH3PXD2B (SH3 and PX domains 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 65.7), Uterus (RPKM 48.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (17422906..17538977)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (16918611..17027499)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (17209152..17296449)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NADPH oxidase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in osteoblast fate commitment	ISO Inferred from Sequence Orthology more info
involved_in podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of brood size	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SH3 and PX domain-containing protein 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398763.1 → NP_001385692.1 SH3 and PX domain-containing protein 2B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6GKH6

Related

ENSRNOP00000005478.7, ENSRNOT00000005478.7

Conserved Domains (6) summary

cd06888
Location:7 → 125

PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein

cd12018
Location:850 → 905

SH3_Tks4_4; Fourth (C-terminal) Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

cd12075
Location:155 → 209

SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

cd12076
Location:224 → 277

SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

cd12078
Location:372 → 424

SH3_Tks4_3; Third Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

PHA03307
Location:433 → 802

PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

17422906..17538977

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087129.2 → XP_038943057.1 SH3 and PX domain-containing protein 2B isoform X2

Conserved Domains (3) summary

cd06888
Location:7 → 125

PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein

cd12075
Location:155 → 209

SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

cl17036
Location:252 → 305

SH3; Src Homology 3 domain superfamily
XM_039087130.2 → XP_038943058.1 SH3 and PX domain-containing protein 2B isoform X4

Conserved Domains (4) summary

cd06888
Location:7 → 125

PX_FISH; The phosphoinositide binding Phox Homology domain of Five SH protein

cd12075
Location:155 → 209

SH3_Tks4_1; First Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

cd12076
Location:252 → 305

SH3_Tks4_2; Second Src homology 3 domain of Tyrosine kinase substrate with four SH3 domains

cl17036
Location:400 → 425

SH3; Src Homology 3 domain superfamily
XM_063268956.1 → XP_063125026.1 SH3 and PX domain-containing protein 2B isoform X3
XM_017597616.3 → XP_017453105.1 SH3 and PX domain-containing protein 2B isoform X1

UniProtKB/TrEMBL

A0A8I6GKH6, M0RCP2

Related

ENSRNOP00000067367.2, ENSRNOT00000073675.5
XM_063268957.1 → XP_063125027.1 SH3 and PX domain-containing protein 2B isoform X5