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    Rps6kc1 ribosomal protein S6 kinase C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289342, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps6kc1provided by RGD
    Official Full Name
    ribosomal protein S6 kinase C1provided by RGD
    Primary source
    RGD:1306578
    See related
    EnsemblRapid:ENSRNOG00000003767 AllianceGenome:RGD:1306578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and phosphatidylinositol binding activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in endosome and lysosome. Predicted to be active in early endosome and postsynaptic density. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 57.2), Thymus (RPKM 34.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps6kc1 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (104877296..105021490, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102346160..102491000, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (109338761..109589209, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096349 Neighboring gene uncharacterized LOC134481636 Neighboring gene uncharacterized LOC134481611 Neighboring gene H3.3 histone B like 1 Neighboring gene angel homolog 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. Liu L, et al. Mol Cells, 2005 Feb 28. PMID 15750338
    2. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase delta-1
    Names
    ribosomal protein S6 kinase, 52kDa, polypeptide 1
    ribosomal protein S6 kinase, polypeptide 1
    ribosomal protein S6 kinase, polypeptide C1
    NP_001402718.1
    NP_001402719.1
    XP_008768052.1
    XP_008768054.1
    XP_038946506.1
    XP_063128247.1
    XP_063128248.1
    XP_063128249.1
    XP_063128250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415789.1 → NP_001402718.1  ribosomal protein S6 kinase delta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZZ58

    2. NM_001415790.1 → NP_001402719.1  ribosomal protein S6 kinase delta-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2KB60, A6JGX5, D3Z991
      Related
      ENSRNOP00000075665.1, ENSRNOT00000087305.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      104877296..105021490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769830.2 → XP_008768052.1  ribosomal protein S6 kinase delta-1 isoform X2

      UniProtKB/TrEMBL
      A6JGX5, D3Z991
      Conserved Domains (5) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      smart00220
      Location:747 → 915
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05576
      Location:738 → 915
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl00299
      Location:140 → 185
      MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl21453
      Location:214 → 300
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039090578.2 → XP_038946506.1  ribosomal protein S6 kinase delta-1 isoform X1

      UniProtKB/TrEMBL
      A6JGX5, D3Z991
      Related
      ENSRNOP00000085010.2, ENSRNOT00000110098.2
      Conserved Domains (4) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd02677
      Location:237 → 305
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:827 → 1004
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:300 → 389
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063272177.1 → XP_063128247.1  ribosomal protein S6 kinase delta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZ58

    4. XM_063272179.1 → XP_063128249.1  ribosomal protein S6 kinase delta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZ58

    5. XM_063272178.1 → XP_063128248.1  ribosomal protein S6 kinase delta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZ58

    6. XM_063272180.1 → XP_063128250.1  ribosomal protein S6 kinase delta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZ58

    7. XM_008769832.4 → XP_008768054.1  ribosomal protein S6 kinase delta-1 isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:552 → 720
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05576
      Location:543 → 720
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:32 → 105
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001840773.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105984.1: Suppressed sequence

      Description
      NM_001105984.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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