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    Maz MYC associated zinc finger protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mazprovided by RGD
    Official Full Name
    MYC associated zinc finger proteinprovided by RGD
    Primary source
    RGD:1594632
    See related
    EnsemblRapid:ENSRNOG00000055082 AllianceGenome:RGD:1594632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pur-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human MAZ (MYC associated zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 197.3), Spleen (RPKM 80.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Maz in Genome Data Viewer
    Location:
    1q37
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191060271..191065722, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181629742..181635193, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198456699..198460126, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene major vault protein Neighboring gene Paxip1-associated glutamate-rich protein 1 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene uncharacterized LOC134483860 Neighboring gene kinesin family member 22 Neighboring gene uncharacterized LOC108349644 Neighboring gene zymogen granule protein 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes. Himeda CL, et al. Mol Cell Biol, 2008 Oct. PMID 18710939, Free PMC Article
    2. MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Bossone SA, et al. Proc Natl Acad Sci U S A, 1992 Aug 15. PMID 1502157, Free PMC Article
    3. MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein. Yao Y, et al. Mol Oncol, 2015 Mar. PMID 25487955, Free PMC Article
    4. Characterization of the murine Ephrin-B2 promoter. Sohl M, et al. Gene, 2009 May 15. PMID 19268698
    5. Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells. Ugai H, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527412

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings are consistent with a previously unrecognized role for MAZ in muscle gene regulation.
      Title: Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes in skeletal and cardiac myocytes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in termination of RNA polymerase II transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myc-associated zinc finger protein
    Names
    purine-binding transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110319.2 → NP_001103789.1  myc-associated zinc finger protein

      See identical proteins and their annotated locations for NP_001103789.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K0R4, A8QJL8
      Conserved Domains (3) summary
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:337 → 357
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:293 → 318
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191060271..191065722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091680.2 → XP_038947608.1  myc-associated zinc finger protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAJ3
      Related
      ENSRNOP00000075418.2, ENSRNOT00000082940.3
      Conserved Domains (3) summary
      COG5048
      Location:254 → 302
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:280 → 337
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:258 → 278
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_063274925.1 → XP_063130995.1  myc-associated zinc finger protein isoform X2

    3. XM_039091677.2 → XP_038947605.1  myc-associated zinc finger protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBK6
      Conserved Domains (2) summary
      COG5189
      Location:303 → 360
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_039091685.2 → XP_038947613.1  myc-associated zinc finger protein isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:277 → 325
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:303 → 360
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:281 → 301
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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