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    Zfp521 zinc finger protein 521 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307579, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp521provided by RGD
    Official Full Name
    zinc finger protein 521provided by RGD
    Primary source
    RGD:1307345
    See related
    EnsemblRapid:ENSRNOG00000016874 AllianceGenome:RGD:1307345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf521
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within neuron fate commitment. Predicted to be located in nucleoplasm. Orthologous to human ZNF521 (zinc finger protein 521). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 50.1), Lung (RPKM 35.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp521 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (5050297..5343188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (4775952..5068592, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (5022042..5315242, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482976 Neighboring gene uncharacterized LOC120098231 Neighboring gene uncharacterized LOC102549314 Neighboring gene uncharacterized LOC108348847 Neighboring gene uncharacterized LOC108348747 Neighboring gene uncharacterized LOC120098248

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Zinc finger protein 521 suppresses osteogenic differentiation of rat mesenchymal stem cells by inhibiting the Wnt/beta-catenin signaling pathway]. Xie XT, et al. Mol Biol (Mosk), 2017 May-Jun. PMID 28707663
    2. Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes an EBFAZ-related Krüppel-like zinc finger protein. Warming S, et al. Blood, 2003 Mar 1. PMID 12393497
    3. Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. Lou S, et al. J Neurosci, 2015 Apr 1. PMID 25834056, Free PMC Article
    4. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Tchernev VT, et al. Mol Med, 2002 Jan. PMID 11984006, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Therefore, we conclude that Zfp521 regulates osteogenic differentiation of rat MSCs through the suppression of the Wnt/beta-catenin signaling pathway.
      Title: [Zinc finger protein 521 suppresses osteogenic differentiation of rat mesenchymal stem cells by inhibiting the Wnt/beta-catenin signaling pathway].
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 521

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107403.2 → NP_001100873.2  zinc finger protein 521 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JT53, A6KLT4
      Conserved Domains (3) summary
      COG5048
      Location:84 → 236
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5236
      Location:785 → 964
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001393860.1 → NP_001380789.1  zinc finger protein 521 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JT53, D3ZQM2
      Related
      ENSRNOP00000022637.6, ENSRNOT00000022637.8
      Conserved Domains (3) summary
      COG5048
      Location:84 → 236
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5236
      Location:785 → 964
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:120 → 140
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      5050297..5343188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277450.1 → XP_063133520.1  zinc finger protein 521 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JT53

    2. XM_063277448.1 → XP_063133518.1  zinc finger protein 521 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JT53

    3. XM_063277447.1 → XP_063133517.1  zinc finger protein 521 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT53
      Related
      ENSRNOP00000068573.2, ENSRNOT00000079682.3

    4. XM_063277453.1 → XP_063133523.1  zinc finger protein 521 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JT53

    5. XM_063277452.1 → XP_063133522.1  zinc finger protein 521 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JT53, A6KLT5

    6. XM_063277449.1 → XP_063133519.1  zinc finger protein 521 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JT53, A6KLT4
    Nucleotide Protein Strain
    Heading Accession and Version

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