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    Cdk11b cyclin-dependent kinase 11B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252879, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk11bprovided by RGD
    Official Full Name
    cyclin-dependent kinase 11Bprovided by RGD
    Primary source
    RGD:628604
    See related
    EnsemblRapid:ENSRNOG00000017213 AllianceGenome:RGD:628604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdk11; Cdc2l1
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of cell growth; and regulation of mRNA processing. Predicted to act upstream of or within blastocyst development; negative regulation of apoptotic signaling pathway; and regulation of mitotic nuclear division. Predicted to be located in nuclear membrane and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to human CDK11A (cyclin dependent kinase 11A) and CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 80.7), Spleen (RPKM 77.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cdk11b in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171495042..171521143)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166212761..166238883)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173051900..173078049)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487048 Neighboring gene solute carrier family 35, member E2B Neighboring gene ribosomal protein L27A like 10 Neighboring gene matrix metallopeptidase 23 Neighboring gene MIB E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    located_in nuclear membrane  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    cyclin-dependent kinase 11B
    Names
    PITSLRE serine/threonine-protein kinase CDC2L1
    cell division cycle 2 homolog-like 1
    cell division cycle 2-like protein kinase 1
    cell division protein kinase 11
    cyclin-dependent kinase 11
    galactosyltransferase-associated protein kinase p58/GTA
    NP_665709.2
    XP_006239591.1
    XP_006239592.1
    XP_006239593.1
    XP_038965218.1
    XP_038965221.1
    XP_038965222.1
    XP_038965223.1
    XP_063143248.1
    XP_063143249.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145766.2NP_665709.2  cyclin-dependent kinase 11B

      See identical proteins and their annotated locations for NP_665709.2

      Status: VALIDATED

      Source sequence(s)
      AA817907, DY544650, DY556124, EX490221, FM031851, FM044847
      UniProtKB/TrEMBL
      D4A3G2
      Related
      ENSRNOP00000023274.6, ENSRNOT00000023274.8
      Conserved Domains (1) summary
      cd07843
      Location:421712
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171495042..171521143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239531.5XP_006239593.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006239593.1

      UniProtKB/TrEMBL
      D3ZML3
      Conserved Domains (2) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390680
      PLN00009; cyclin-dependent kinase A; Provisional
    2. XM_063287179.1XP_063143249.1  cyclin-dependent kinase 11B isoform X4

    3. XM_006239530.4XP_006239592.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006239592.1

      UniProtKB/TrEMBL
      D3ZML3
      Conserved Domains (2) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390680
      PLN00009; cyclin-dependent kinase A; Provisional
    4. XM_063287178.1XP_063143248.1  cyclin-dependent kinase 11B isoform X1

    5. XM_039109290.2XP_038965218.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/TrEMBL
      A6IUR2
      Conserved Domains (1) summary
      cd07843
      Location:420711
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    6. XM_006239529.5XP_006239591.1  cyclin-dependent kinase 11B isoform X3

      See identical proteins and their annotated locations for XP_006239591.1

      UniProtKB/TrEMBL
      D3ZML3
      Related
      ENSRNOP00000039105.5, ENSRNOT00000050188.6
      Conserved Domains (2) summary
      cd07843
      Location:387678
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:390680
      PLN00009; cyclin-dependent kinase A; Provisional
    7. XM_039109294.2XP_038965222.1  cyclin-dependent kinase 11B isoform X6

      Conserved Domains (1) summary
      cd07843
      Location:204495
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    8. XM_039109293.2XP_038965221.1  cyclin-dependent kinase 11B isoform X5

      Conserved Domains (1) summary
      cd07843
      Location:225516
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    9. XM_039109295.2XP_038965223.1  cyclin-dependent kinase 11B isoform X7

      UniProtKB/Swiss-Prot
      P46892
      Related
      ENSRNOP00000100557.1, ENSRNOT00000160153.1
      Conserved Domains (1) summary
      cd07843
      Location:76367
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
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