Bnip3l BCL2 interacting protein 3 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bnip3lprovided by RGD
Official Full Name: BCL2 interacting protein 3 likeprovided by RGD
Primary source: RGD:621354
See related: EnsemblRapid:ENSRNOG00000009820 AllianceGenome:RGD:621354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nix; UV93
Summary: Predicted to enable lamin binding activity and protein homodimerization activity. Involved in negative regulation of mitochondrial membrane potential; positive regulation of apoptotic process; and positive regulation of mitochondrial membrane permeability. Predicted to be located in endoplasmic reticulum; mitochondrial outer membrane; and nucleus. Biomarker of gestational diabetes; metabolic dysfunction-associated steatohepatitis; middle cerebral artery infarction; and pancreatitis. Orthologous to human BNIP3L (BCL2 interacting protein 3 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 603.7), Lung (RPKM 361.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (45350081..45373213, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (41174594..41197730, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (43643897..43667123, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NIX Mediates Mitophagy in Spinal Cord Injury in Rats by Interacting with LC3.
Title: NIX Mediates Mitophagy in Spinal Cord Injury in Rats by Interacting with LC3.
Hyperoxia exposure arrests alveolarization in neonatal rats via PTENinduced putative kinase 1Parkin and Nip3like protein Xmediated mitophagy disorders.
Title: Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders.
VNS treatment benefited CSHF via the up-regulation of miRNA-183-3p, which reduced the BNIP3L-mediated autophagy.
Title: MicroRNA-183-3p up-regulated by vagus nerve stimulation mitigates chronic systolic heart failure via the reduction of BNIP3L-mediated autophagy.
BNIP3L is a novel mediator of pressure overload-induced cardiac fibrosis through the [Ca(2+)]i-TGF-beta-Smad2/3 pathway in CFs.
Title: BNIP3L promotes cardiac fibrosis in cardiac fibroblasts through [Ca(2+)](i)-TGF-β-Smad2/3 pathway.
p75(NTR) and NIX may play critical roles in intracerebral hemorrhage-induced neuronal apoptosis in vitro and in vivo.
Title: p75 neurotrophin receptor and its novel interaction partner, NIX, are involved in neuronal apoptosis after intracerebral hemorrhage.
overexpression of BNIP3L in H9C2 cardiomyoblast cells reduced the cardioprotection of FGF-2 in hydrogen peroxide-induced necrosis and mitochondrial dysfunction.
Title: FGF-2 Transcriptionally Down-Regulates the Expression of BNIP3L via PI3K/Akt/FoxO3a Signaling and Inhibits Necrosis and Mitochondrial Dysfunction Induced by High Concentrations of Hydrogen Peroxide in H9c2 Cells.
Up-regulated expression of Bnip3L might be involved in the pathophysiology of intracerebral hemorrhage in rats.
Title: Up-regulated expression of Bnip3L after intracerebral hemorrhage in adult rats.
-stimulated cytoplasmic-nuclear shuttling of the alternately spliced non-mitochondrial Nix isoform and uncover a role for sNix as a modulator of TNFalpha/NFkappaB-stimulated cardiac gene expression
Title: A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription.
three members of the BNIP family, BNIP1, BNIP3 and BNIP3L, are expressed in the developing brain with distinct brain region specificity
Title: Differential expression of BNIP family members of BH3-only proteins during the development and after axotomy in the rat.
The proapoptotic protein Nix/Bnip3L was found to be a potential GABARAP ligand.
Title: Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH140982 (e-PCR)
- UniSTS:222983

RH140685 (e-PCR)
- UniSTS:222753

RH133328 (e-PCR)
- UniSTS:216611

AW532315 (e-PCR)
- UniSTS:245572

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Names: BCL2/adenovirus E1B 19 kDa-interacting protein 3-like; BCL2/adenovirus E1B interacting protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080888.3 → NP_543164.2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6K6N6, F7FMM7, Q4G086, Q8VBW4

Related

ENSRNOP00000014798.4, ENSRNOT00000014798.7

Conserved Domains (1) summary

pfam06553
Location:27 → 217

BNIP3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

45350081..45373213 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599570.3 → XP_017455059.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X4

UniProtKB/TrEMBL

A0A8I6AKI3, Q8VBW4

Related

ENSRNOP00000092276.2, ENSRNOT00000095519.2
XM_039092964.2 → XP_038948892.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X2

UniProtKB/TrEMBL

A0A8I6AG85

Conserved Domains (1) summary

pfam06553
Location:58 → 242

BNIP3
XM_006252091.4 → XP_006252153.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X5

UniProtKB/TrEMBL

Q8VBW4

Conserved Domains (1) summary

pfam06553
Location:17 → 178

BNIP3
XM_039092962.2 → XP_038948890.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1

UniProtKB/TrEMBL

A0A8I6AG85

Conserved Domains (1) summary

pfam06553
Location:62 → 246

BNIP3
XM_039092965.2 → XP_038948893.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X3

UniProtKB/TrEMBL

A0A8I6AG85

Conserved Domains (1) summary

pfam06553
Location:62 → 232

BNIP3