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    DCLK3 doublecortin like kinase 3 [ Homo sapiens (human) ]

    Gene ID: 85443, updated on 27-Dec-2024

    Summary

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    Official Symbol
    DCLK3provided by HGNC
    Official Full Name
    doublecortin like kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:19005
    See related
    Ensembl:ENSG00000163673 MIM:613167; AllianceGenome:HGNC:19005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLR; DCK3; DCDC3C; DCAMKL3
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in protein localization to nucleus. Predicted to act upstream of or within negative regulation of protein localization to nucleus and peptidyl-serine phosphorylation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 2.2), brain (RPKM 0.5) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCLK3 in Genome Data Viewer
    Location:
    3p22.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (36712421..36764553, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (36713774..36765897, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (36753912..36806044, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NBPF member 21, pseudogene Neighboring gene RN7SK pseudogene 227 Neighboring gene NANOG hESC enhancer GRCh37_chr3:36739560-36740214 Neighboring gene Sharpr-MPRA regulatory region 13437 Neighboring gene uncharacterized LOC105377029 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Wierinckx A, et al. Endocr Relat Cancer, 2007 Sep. PMID 17914117
    2. Bacterial expression and purification of a heterodimeric adrenomedullin receptor extracellular domain complex using DsbC-assisted disulfide shuffling. Hill HE, et al. Protein Expr Purif, 2013 Mar. PMID 23247088, Free PMC Article
    3. Refolding and characterization of a soluble ectodomain complex of the calcitonin gene-related peptide receptor. Koth CM, et al. Biochemistry, 2010 Mar 9. PMID 20099900
    4. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. Ohmae S, et al. J Biol Chem, 2006 Jul 21. PMID 16684769
    5. The doublecortin gene family and disorders of neuronal structure. Dijkmans TF, et al. Cent Nerv Syst Agents Med Chem, 2010 Mar. PMID 20236041

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1765

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase DCLK3
    Names
    CLICK-I,II-related
    doublecortin and CaM kinase-like 3
    doublecortin domain-containing protein 3C
    doublecortin-like and CAM kinase-like 3
    NP_001381601.1
    NP_208382.1
    XP_047305046.1
    XP_054204134.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394672.2 → NP_001381601.1  serine/threonine-protein kinase DCLK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC105749
      Consensus CDS
      CCDS93239.1
      UniProtKB/TrEMBL
      A0A1B0GTZ4
      Related
      ENSP00000489900.1, ENST00000636136.2
      Conserved Domains (2) summary
      cd14185
      Location:524 → 781
      STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)
      cd16111
      Location:93 → 177
      DCX_DCLK3; Doublecortin-like domain found in doublecortin-like kinase 3 (DCLK3)

    2. NM_033403.1 → NP_208382.1  serine/threonine-protein kinase DCLK3 isoform 2

      See identical proteins and their annotated locations for NP_208382.1

      Status: VALIDATED

      Source sequence(s)
      AB051552, AC105749, AK122988, DB075681, DR000236
      Consensus CDS
      CCDS43064.1
      UniProtKB/Swiss-Prot
      Q9C098
      UniProtKB/TrEMBL
      B3KVM3
      Related
      ENSP00000394484.2, ENST00000416516.2
      Conserved Domains (2) summary
      smart00220
      Location:356 → 613
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14185
      Location:355 → 612
      STKc_DCKL3; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      36712421..36764553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449090.1 → XP_047305046.1  serine/threonine-protein kinase DCLK3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      36713774..36765897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348159.1 → XP_054204134.1  serine/threonine-protein kinase DCLK3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C098.2 GenPept UniProtKB/Swiss-Prot:Q9C098

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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