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    ARID3C AT-rich interaction domain 3C [ Homo sapiens (human) ]

    Gene ID: 138715, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ARID3Cprovided by HGNC
    Official Full Name
    AT-rich interaction domain 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:21209
    See related
    Ensembl:ENSG00000205143 MIM:620868; AllianceGenome:HGNC:21209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

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    See ARID3C in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34621049..34633011, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34639596..34650042, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34621046..34629063, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34611012-34611565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19850 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28312 Neighboring gene ribonuclease P/MRP subunit p25 like Neighboring gene dynactin subunit 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34624191-34624739 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19853 Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene Sharpr-MPRA regulatory region 8240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28314 Neighboring gene galactose-1-phosphate uridylyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ARID3C Acts as a Regulator of Monocyte-to-Macrophage Differentiation Interacting with NPM1. Kim HS, et al. J Proteome Res, 2024 Aug 2. PMID 38231884,
    2. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. Wilsker D, et al. Cell Growth Differ, 2002 Mar. PMID 11959810
    3. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription. Tidwell JA, et al. Mol Immunol, 2011 Oct. PMID 21955986, Free PMC Article
    4. Nomenclature of the ARID family of DNA-binding proteins. Wilsker D, et al. Genomics, 2005 Aug. PMID 15922553
    5. ARID proteins come in from the desert. Kortschak RD, et al. Trends Biochem Sci, 2000 Jun. PMID 10838570

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this report introduces Brightlike as an additional functional member of the family of ARID proteins, which should be considered in regulatory circuits, previously ascribed to be mediated by Bright.[ARID3C]
      Title: Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AT-rich interactive domain-containing protein 3C
    Names
    ARID domain-containing protein 3C
    AT rich interactive domain 3C (BRIGHT-like)
    Brightlike

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017363.4 → NP_001017363.1  AT-rich interactive domain-containing protein 3C isoform 1

      See identical proteins and their annotated locations for NP_001017363.1

      Status: VALIDATED

      Source sequence(s)
      AL450283
      Consensus CDS
      CCDS35006.1
      UniProtKB/Swiss-Prot
      A6NKF2
      Related
      ENSP00000368189.2, ENST00000378909.4
      Conserved Domains (1) summary
      cl28902
      Location:101 → 227
      ARID; ARID/BRIGHT DNA binding domain family

    2. NM_001371945.2 → NP_001358874.1  AT-rich interactive domain-containing protein 3C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL450283
      UniProtKB/TrEMBL
      A0A8I5QL24
      Related
      ENSP00000510553.1, ENST00000692051.1
      Conserved Domains (1) summary
      cd16880
      Location:101 → 227
      ARID_ARID3C; ARID/BRIGHT DNA binding domain of AT-rich interactive domain-containing protein 3C (ARID3C) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      34621049..34633011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422781.1 → XP_047278737.1  AT-rich interactive domain-containing protein 3C isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      34639596..34650042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361993.1 → XP_054217968.1  AT-rich interactive domain-containing protein 3C isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NKF2.1 GenPept UniProtKB/Swiss-Prot:A6NKF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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