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    Gng8 G protein subunit gamma 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gng8provided by RGD
    Official Full Name
    G protein subunit gamma 8provided by RGD
    Primary source
    RGD:620808
    See related
    EnsemblRapid:ENSRNOG00000016701 AllianceGenome:RGD:620808
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg3e
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Involved in nervous system development. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG8 (G protein subunit gamma 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 118.3), Spleen (RPKM 28.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gng8 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86692609..86696463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77564512..77568371)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78818360..78822224)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein kinase D2 Neighboring gene transfer RNA proline (anticodon CGG) Neighboring gene dishevelled-binding antagonist of beta-catenin 3 Neighboring gene prostaglandin I2 receptor Neighboring gene calmodulin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during neurogenesis in the olfactory and vomeronasal neuroepithelia. Ryba NJ, et al. J Biol Chem, 1995 Mar 24. PMID 7896821
    2. Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. Montani G, et al. J Physiol, 2013 Aug 15. PMID 23836683, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to pheromone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within nose development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Names
    G-protein gamma 8 subunit
    gamma-9
    guanine nucleotide binding protein (G protein), gamma 8 subunit
    heterotrimeric guanine nucleotide-binding protein 3e

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139185.2 → NP_631924.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      See identical proteins and their annotated locations for NP_631924.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P63077
      UniProtKB/TrEMBL
      A6J8D6
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      86692609..86696463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098799.2 → XP_038954727.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      P63077
      UniProtKB/TrEMBL
      A6J8D6
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs

    2. XM_006228384.5 → XP_006228446.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      See identical proteins and their annotated locations for XP_006228446.1

      UniProtKB/Swiss-Prot
      P63077
      UniProtKB/TrEMBL
      A6J8D6
      Related
      ENSRNOP00000072099.1, ENSRNOT00000090417.3
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63077.1 GenPept UniProtKB/Swiss-Prot:P63077

    Gene LinkOut

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