Pde8a phosphodiesterase 8A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pde8aprovided by RGD
Official Full Name: phosphodiesterase 8Aprovided by RGD
Primary source: RGD:735125
See related: EnsemblRapid:ENSRNOG00000019005 AllianceGenome:RGD:735125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RNPDE8A
Summary: Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity; kinase binding activity; and protein kinase activator activity. Predicted to be involved in cAMP-mediated signaling; cellular response to epidermal growth factor stimulus; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 166.4), Kidney (RPKM 127.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144575203..144698216)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (135166143..135288986)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (143036083..143160395)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The neurons exhibiting PDE8A-immunoreactivity were widely distributed in the forebrain, brain stem, and cerebellum. Strongly immunoreactive neurons were located in the olfactory bulb, the septal area, zona incerta, and reticular nucleus of the thalamus.
Title: Distribution of PDE8A in the nervous system of the Sprague-Dawley rat.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140728 (e-PCR)
- UniSTS:222794

RH143306 (e-PCR)
- UniSTS:232553

21.MMHAP17FRG9.seq (e-PCR)
- UniSTS:123510

Pde8a (e-PCR), detects polymorphism
- UniSTS:498350

AI556676 (e-PCR)
- UniSTS:226259

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cAMP catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to epidermal growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Names: cAMP-specific cyclic nucleotide phosphodiesterase PDE8

NP_942062.1

EC 3.1.4.17

XP_006229500.1

EC 3.1.4.17

XP_038968970.2

EC 3.1.4.17

XP_038968971.2

EC 3.1.4.17

XP_038968972.2

EC 3.1.4.17

XP_038968973.1

EC 3.1.4.17

XP_063118773.1

EC 3.1.4.17

XP_063118774.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198767.1 → NP_942062.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

See identical proteins and their annotated locations for NP_942062.1

Status: PROVISIONAL

Source sequence(s)

AB092696

UniProtKB/TrEMBL

A6JCF1, Q76KC6

Conserved Domains (4) summary

cd00130
Location:224 → 318

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00233
Location:548 → 801

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam08629
Location:1 → 44

PDE8; PDE8 phosphodiesterase

pfam13426
Location:220 → 318

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

144575203..144698216

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262703.1 → XP_063118773.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

UniProtKB/TrEMBL

A6JCF1
XM_006229438.5 → XP_006229500.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

See identical proteins and their annotated locations for XP_006229500.1

UniProtKB/TrEMBL

A6JCF1, Q76KC6

Related

ENSRNOP00000025797.3, ENSRNOT00000025797.5

Conserved Domains (4) summary

cd00130
Location:224 → 318

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00233
Location:548 → 801

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam08629
Location:1 → 44

PDE8; PDE8 phosphodiesterase

pfam13426
Location:220 → 318

PAS_9; PAS domain
XM_063262704.1 → XP_063118774.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

UniProtKB/TrEMBL

A0A8I5ZXE4
XM_039113045.2 → XP_038968973.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X6

Conserved Domains (3) summary

COG2202
Location:118 → 318

PAS; PAS domain [Signal transduction mechanisms]

pfam08629
Location:1 → 24

PDE8; PDE8 phosphodiesterase

pfam13426
Location:220 → 318

PAS_9; PAS domain
XM_039113042.2 → XP_038968970.2 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

UniProtKB/TrEMBL

A0A8I6ABI0
XM_039113043.2 → XP_038968971.2 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

UniProtKB/TrEMBL

A0A8I6ABI0
XM_039113044.2 → XP_038968972.2 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X5