Apba1 amyloid beta precursor protein binding family A member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apba1provided by RGD
Official Full Name: amyloid beta precursor protein binding family A member 1provided by RGD
Primary source: RGD:620844
See related: EnsemblRapid:ENSRNOG00000014928 AllianceGenome:RGD:620844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mint1
Summary: Enables several functions, including PDZ domain binding activity; amyloid-beta binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within several processes, including carboxylic acid transport; in utero embryonic development; and locomotory behavior. Located in dendritic spine. Part of protein-containing complex. Orthologous to human APBA1 (amyloid beta precursor protein binding family A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 141.5), Testes (RPKM 25.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (230790297..230995986)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (221363769..221569496)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (241594565..241796512)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CASK, APBA1, and STXBP1 collaborate during insulin secretion.
Title: CASK, APBA1, and STXBP1 collaborate during insulin secretion.
Data show that scaffold protein X11alpha modulates kalirin-7 localization in dendrites and recruits it to Golgi outposts.
Title: Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.
Upon neurodegeneration with okadaic acid, mint-1 and mint-2 levels were reduced by proteolytic cleavage, and these changes were followed by increases in APP levels.
Title: Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons.
a complex composed of SAP97, CASK, Veli, and Mint1 associates with Kir2 channels via the C-terminal PDZ-binding motif. SAP97, Veli-1, or Veli-3 binds directly to the Kir2.2 C terminus and recruits CASK
Title: A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.
Western blotting showed that Mint1 was expressed in hamster (HIT-T15) and rat (RINm5F) beta-cell lines.
Title: Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells.
neuroserpin interacts with Abeta(1-42) to form off-pathway non-toxic oligomers and so protects neurons in Alzheimer disease
Title: Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mlf2 (e-PCR), detects polymorphism
- UniSTS:526900

D1Got221 (e-PCR)
- UniSTS:113007

BF393522 (e-PCR)
- UniSTS:244129

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in glutamate secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: amyloid-beta A4 precursor protein-binding family A member 1

Names: adapter protein X11alpha; amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11); amyloid beta (A4) precursor protein-binding, family A, member 1; mint-1; neuron-specific X11 protein; neuronal Munc18-1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031779.3 → NP_113967.2 amyloid-beta A4 precursor protein-binding family A member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35430

UniProtKB/TrEMBL

A6I0P3, F1LR60

Related

ENSRNOP00000020123.4, ENSRNOT00000020123.6

Conserved Domains (3) summary

cd00992
Location:749 → 822

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:456 → 627

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:660 → 743

PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

230790297..230995986

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275486.1 → XP_063131556.1 amyloid-beta A4 precursor protein-binding family A member 1 isoform X1

UniProtKB/Swiss-Prot

O35430
XM_063275480.1 → XP_063131550.1 amyloid-beta A4 precursor protein-binding family A member 1 isoform X1

UniProtKB/Swiss-Prot

O35430
XM_039092551.2 → XP_038948479.1 amyloid-beta A4 precursor protein-binding family A member 1 isoform X2

UniProtKB/Swiss-Prot

O35430

UniProtKB/TrEMBL

A0A8I6A9Y2

Related

ENSRNOP00000089303.2, ENSRNOT00000094213.2

Conserved Domains (3) summary

cd00992
Location:738 → 811

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01208
Location:456 → 616

PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain

pfam00595
Location:649 → 732

PDZ; PDZ domain (Also known as DHR or GLGF)