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    Lzts2 leucine zipper tumor suppressor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lzts2provided by RGD
    Official Full Name
    leucine zipper tumor suppressor 2provided by RGD
    Primary source
    RGD:1359249
    See related
    EnsemblRapid:ENSRNOG00000014969 AllianceGenome:RGD:1359249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lapser1
    Summary
    Involved in negative regulation of fibroblast proliferation and positive regulation of apoptotic process. Located in centrosome; midbody; and mitotic spindle pole. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 56.3), Heart (RPKM 51.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lzts2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (253824073..253837614)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (243876665..243888489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (264765256..264776553)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene semaphorin 4G Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene PDZ domain containing 7 Neighboring gene sideroflexin 3 Neighboring gene Kazal-type serine peptidase inhibitor domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin. Sudo H, et al. FASEB J, 2007 Jul. PMID 17351128
    2. Deletion of leucine zipper tumor suppressor 2 (Lzts2) increases susceptibility to tumor development. Johnson DT, et al. J Biol Chem, 2013 Feb 8. PMID 23275340, Free PMC Article
    3. Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses. Schmeisser MJ, et al. J Biol Chem, 2009 Oct 16. PMID 19703901, Free PMC Article
    4. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. Peng Y, et al. J Biol Chem, 2011 Nov 18. PMID 21949185, Free PMC Article
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses
      Title: Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses.
    2. LAPSER1 localizes to the centrosomes & midbodies in mitotic cells. LAPSER1 participates in cytokinesis by interacting with p80 katanin, the disruption of which may potentially cause genetic instability and cancer.
      Title: LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule severing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in primary ureteric bud growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within primary ureteric bud growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle midzone assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ureter morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ureter morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 2
    Names
    protein LAPSER1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014247.2 → NP_001014269.2  leucine zipper putative tumor suppressor 2

      See identical proteins and their annotated locations for NP_001014269.2

      Status: VALIDATED

      Source sequence(s)
      BC083580, DN932851, DQ176638
      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6
      Conserved Domains (2) summary
      pfam06818
      Location:440 → 636
      Fez1; Fez1
      pfam15960
      Location:503 → 619
      DUF4763; Domain of unknown function (DUF4763)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      253824073..253837614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270009.1 → XP_063126079.1  leucine zipper putative tumor suppressor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6

    2. XM_017589509.3 → XP_017444998.1  leucine zipper putative tumor suppressor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6
      Conserved Domains (2) summary
      pfam06818
      Location:440 → 636
      Fez1; Fez1
      pfam15960
      Location:503 → 619
      DUF4763; Domain of unknown function (DUF4763)

    3. XM_017589508.3 → XP_017444997.1  leucine zipper putative tumor suppressor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6
      Conserved Domains (2) summary
      pfam06818
      Location:440 → 636
      Fez1; Fez1
      pfam15960
      Location:503 → 619
      DUF4763; Domain of unknown function (DUF4763)

    4. XM_006231549.5 → XP_006231611.1  leucine zipper putative tumor suppressor 2 isoform X1

      See identical proteins and their annotated locations for XP_006231611.1

      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6
      Conserved Domains (2) summary
      pfam06818
      Location:440 → 636
      Fez1; Fez1
      pfam15960
      Location:503 → 619
      DUF4763; Domain of unknown function (DUF4763)

    5. XM_063270014.1 → XP_063126084.1  leucine zipper putative tumor suppressor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6

    6. XM_006231547.5 → XP_006231609.1  leucine zipper putative tumor suppressor 2 isoform X1

      See identical proteins and their annotated locations for XP_006231609.1

      UniProtKB/Swiss-Prot
      Q24K74, Q3LUD4
      UniProtKB/TrEMBL
      F7FLS6
      Related
      ENSRNOP00000042095.4, ENSRNOT00000048843.7
      Conserved Domains (2) summary
      pfam06818
      Location:440 → 636
      Fez1; Fez1
      pfam15960
      Location:503 → 619
      DUF4763; Domain of unknown function (DUF4763)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3LUD4.2 GenPept UniProtKB/Swiss-Prot:Q3LUD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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