Fbxl15 F-box and leucine-rich repeat protein 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbxl15provided by RGD
Official Full Name: F-box and leucine-rich repeat protein 15provided by RGD
Primary source: RGD:1306444
See related: EnsemblRapid:ENSRNOG00000019509 AllianceGenome:RGD:1306444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306444
Summary: Involved in bone mineralization. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL15 (F-box and leucine rich repeat protein 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 44.2), Kidney (RPKM 32.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255131154..255133395)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245189732..245191973)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266075782..266078023)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXL15 is a key regulator of BMP signalling during embryonic development and adult bone formation.
Title: SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_11963-11964:1003864532:1 (e-PCR)
- UniSTS:267295

AW434352 (e-PCR)
- UniSTS:248775

RH140950 (e-PCR)
- UniSTS:222951

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 15

Names: F-box only protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107603.1 → NP_001101073.1 F-box/LRR-repeat protein 15

See identical proteins and their annotated locations for NP_001101073.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/Swiss-Prot

D4ABB4

Related

ENSRNOP00000026471.5, ENSRNOT00000026471.7

Conserved Domains (3) summary

cd09293
Location:139 → 268

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:62 → 88

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00646
Location:18 → 55

F-box; F-box domain