Slc2a12 solute carrier family 2 member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc2a12provided by RGD
Official Full Name: solute carrier family 2 member 12provided by RGD
Primary source: RGD:1310175
See related: EnsemblRapid:ENSRNOG00000011161 AllianceGenome:RGD:1310175
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable D-glucose transmembrane transporter activity and symporter activity. Predicted to be involved in D-glucose transmembrane transport and circulatory system development. Predicted to be located in endomembrane system; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in membrane. Orthologous to human SLC2A12 (solute carrier family 2 member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 77.0), Uterus (RPKM 55.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (24623558..24683577, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (22803068..22862204, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (24003625..24056373, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D1Got31 (e-PCR)
- UniSTS:113243

Slc2a12 (e-PCR), detects polymorphism
- UniSTS:463965

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in D-glucose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 12

Names: solute carrier family 2 (facilitated glucose transporter), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107451.1 → NP_001100921.1 solute carrier family 2, facilitated glucose transporter member 12

See identical proteins and their annotated locations for NP_001100921.1

Status: PROVISIONAL

Source sequence(s)

CH474002

UniProtKB/TrEMBL

A0A8I6A9T2, A6JUP8, D3ZNG4

Related

ENSRNOP00000015566.5, ENSRNOT00000015566.7

Conserved Domains (1) summary

cd17435
Location:46 → 564

MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

24623558..24683577 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110423.2 → XP_038966351.1 solute carrier family 2, facilitated glucose transporter member 12 isoform X1

UniProtKB/TrEMBL

A0A8I6A9T2, A6JUP8, D3ZNG4

Conserved Domains (1) summary

cd17435
Location:46 → 564

MFS_GLUT12_Class3; Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters
XM_039110427.2 → XP_038966355.1 solute carrier family 2, facilitated glucose transporter member 12 isoform X2

Conserved Domains (1) summary

cl28910
Location:46 → 367

MFS; Major Facilitator Superfamily