Lilrc2 leukocyte immunoglobulin-like receptor, subfamily C, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lilrc2provided by RGD
Official Full Name: leukocyte immunoglobulin-like receptor, subfamily C, member 2provided by RGD
Primary source: RGD:1589872
See related: EnsemblRapid:ENSRNOG00000058087 AllianceGenome:RGD:1589872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 34.2), Lung (RPKM 30.1) and 9 other tissues See more
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Genomic context

Location:: 1q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (74187623..74192646, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (65272134..65277278, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (63679228..63684265, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LILRC1 and LILRC2 both have two extracellular Ig-like domains and a cytoplasmic tail devoid of any known signaling motifs. The transmembrane regions contain an arginine residue.
Title: Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte immunoglobulin-like receptor, subfamily C, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100123.1 → NP_001093593.1 leukocyte immunoglobulin-like receptor, subfamily C, member 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4AAQ4

Related

ENSRNOP00000068636.1, ENSRNOT00000085651.3

Conserved Domains (1) summary

cl11960
Location:45 → 136

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

74187623..74192646 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228170.5 → XP_006228232.1 leukocyte immunoglobulin-like receptor, subfamily C, member 2 isoform X2

Conserved Domains (1) summary

cl11960
Location:45 → 136

Ig; Immunoglobulin domain
XM_039091526.2 → XP_038947454.1 leukocyte immunoglobulin-like receptor, subfamily C, member 2 isoform X3

Conserved Domains (2) summary

cd00096
Location:47 → 51

Ig; Ig strand A [structural motif]

cl11960
Location:46 → 140

Ig; Immunoglobulin domain
XM_063274824.1 → XP_063130894.1 leukocyte immunoglobulin-like receptor, subfamily C, member 2 isoform X1
XM_063274825.1 → XP_063130895.1 leukocyte immunoglobulin-like receptor, subfamily C, member 2 isoform X4