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    Nsmce1 NSE1 homolog, SMC5-SMC6 complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nsmce1provided by RGD
    Official Full Name
    NSE1 homolog, SMC5-SMC6 complex componentprovided by RGD
    Primary source
    RGD:1307760
    See related
    EnsemblRapid:ENSRNOG00000015218 AllianceGenome:RGD:1307760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307760
    Summary
    Predicted to enable protein dimerization activity and ubiquitin protein ligase activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be located in chromosome, centromeric region; mitotic spindle pole; and nucleoplasm. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 79.8), Testes (RPKM 67.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsmce1 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (189462801..189489188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180030355..180058541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (196857490..196883907, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097358 Neighboring gene lysine demethylase 8 Neighboring gene uncharacterized LOC103691233 Neighboring gene interleukin 4 receptor Neighboring gene uncharacterized LOC120097359

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. van der Crabben SN, et al. J Clin Invest, 2016 Aug 1. PMID 27427983, Free PMC Article
    2. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Taylor EM, et al. Mol Cell Biol, 2008 Feb. PMID 18086888, Free PMC Article
    3. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Doyle JM, et al. Mol Cell, 2010 Sep 24. PMID 20864041, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC124662

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    non-structural maintenance of chromosomes element 1 homolog
    Names
    non-SMC element 1 homolog
    NP_001034700.1
    XP_006230353.1
    XP_006230355.1
    XP_038938809.1
    XP_063123727.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039611.1 → NP_001034700.1  non-structural maintenance of chromosomes element 1 homolog

      See identical proteins and their annotated locations for NP_001034700.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099757
      UniProtKB/TrEMBL
      A0A0G2JSX1, A0A8I6A8T8
      Related
      ENSRNOP00000051912.2, ENSRNOT00000055034.3
      Conserved Domains (2) summary
      pfam07574
      Location:40 → 199
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:215 → 255
      zf-RING-like; RING-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      189462801..189489188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230291.5 → XP_006230353.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006230353.1

      UniProtKB/Swiss-Prot
      Q499U6
      UniProtKB/TrEMBL
      A0A8I6A8T8, A6I913
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    2. XM_063267657.1 → XP_063123727.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q499U6
      UniProtKB/TrEMBL
      A0A8I6A8T8, A6I913

    3. XM_006230293.5 → XP_006230355.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006230355.1

      UniProtKB/Swiss-Prot
      Q499U6
      UniProtKB/TrEMBL
      A0A8I6A8T8, A6I913
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    4. XM_039082881.2 → XP_038938809.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q499U6
      UniProtKB/TrEMBL
      A0A8I6A8T8, A6I913
      Related
      ENSRNOP00000071768.3, ENSRNOT00000089464.3
      Conserved Domains (2) summary
      cd16493
      Location:190 → 234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16 → 175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499U6.2 GenPept UniProtKB/Swiss-Prot:Q499U6

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