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    Lmntd2 lamin tail domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmntd2provided by RGD
    Official Full Name
    lamin tail domain containing 2provided by RGD
    Primary source
    RGD:1307439
    See related
    EnsemblRapid:ENSRNOG00000017050 AllianceGenome:RGD:1307439
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307439
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in lamin filament. Orthologous to human LMNTD2 (lamin tail domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 145.8) and Kidney (RPKM 11.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmntd2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205744694..205750460, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196315112..196320880, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214197126..214202828, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene HRas proto-oncogene, GTPase Neighboring gene leucine rich repeat containing 56 Neighboring gene uncharacterized LOC102553043 Neighboring gene Ras association domain family member 7 Neighboring gene microRNA 3574 Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lamin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lamin tail domain-containing protein 2
    Names
    uncharacterized protein C11orf35 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127540.1 → NP_001121012.1  lamin tail domain-containing protein 2

      See identical proteins and their annotated locations for NP_001121012.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162052
      UniProtKB/TrEMBL
      A6HXR3, B1WC94
      Related
      ENSRNOP00000022954.5, ENSRNOT00000022954.8
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205744694..205750460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263936.1 → XP_063120006.1  lamin tail domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6HXR3

    2. XM_017589231.3 → XP_017444720.1  lamin tail domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZM60, A6HXR3
      Related
      ENSRNOP00000079106.1, ENSRNOT00000112367.2
      Conserved Domains (1) summary
      pfam00932
      Location:361 → 453
      LTD; Lamin Tail Domain

    3. XM_006230554.4 → XP_006230616.1  lamin tail domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006230616.1

      UniProtKB/TrEMBL
      A6HXR3, B1WC94
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    4. XM_063263917.1 → XP_063119987.1  lamin tail domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HXR3

    5. XM_063263941.1 → XP_063120011.1  lamin tail domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6HXR3

    6. XM_063263921.1 → XP_063119991.1  lamin tail domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HXR3

    7. XM_063263945.1 → XP_063120015.1  lamin tail domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZM60, A6HXR3

    8. XM_006230555.5 → XP_006230617.1  lamin tail domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006230617.1

      UniProtKB/TrEMBL
      A6HXR3, B1WC94
      Conserved Domains (1) summary
      pfam00932
      Location:385 → 477
      LTD; Lamin Tail Domain

    9. XM_063263930.1 → XP_063120000.1  lamin tail domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A6HXR3, B1WC94

    10. XM_063263924.1 → XP_063119994.1  lamin tail domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HXR3

    11. XM_063263947.1 → XP_063120017.1  lamin tail domain-containing protein 2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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