Peli3 pellino E3 ubiquitin protein ligase family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Peli3provided by RGD
Official Full Name: pellino E3 ubiquitin protein ligase family member 3provided by RGD
Primary source: RGD:1305989
See related: EnsemblRapid:ENSRNOG00000019950 AllianceGenome:RGD:1305989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305989
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein K63-linked ubiquitination. Predicted to act upstream of or within defense response to Gram-negative bacterium; negative regulation of macromolecule metabolic process; and regulation of signal transduction. Orthologous to human PELI3 (pellino E3 ubiquitin protein ligase family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 36.7), Adrenal (RPKM 21.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (211659416..211672280, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202230034..202242900, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220191209..220204032, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Toll signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase pellino homolog 3

Names: pellino 3; pellino homolog 3; protein pellino homolog 3

NP_001121014.1

EC 2.3.2.27

XP_038935371.1

EC 2.3.2.27

XP_038935381.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127542.1 → NP_001121014.1 E3 ubiquitin-protein ligase pellino homolog 3

See identical proteins and their annotated locations for NP_001121014.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A0A8I6AFG2, A6HZ08, A6HZ09, B1WBX1, F7EWH3

Related

ENSRNOP00000027038.2, ENSRNOT00000027038.5

Conserved Domains (1) summary

pfam04710
Location:37 → 445

Pellino

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

211659416..211672280 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079443.2 → XP_038935371.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform X1

Conserved Domains (1) summary

pfam04710
Location:1 → 362

Pellino
XM_039079453.1 → XP_038935381.1 E3 ubiquitin-protein ligase pellino homolog 3 isoform X2

Conserved Domains (1) summary

pfam04710
Location:1 → 320

Pellino