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    Atad1 ATPase family, AAA domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atad1provided by RGD
    Official Full Name
    ATPase family, AAA domain containing 1provided by RGD
    Primary source
    RGD:1308570
    See related
    EnsemblRapid:ENSRNOG00000010861 AllianceGenome:RGD:1308570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ab2-088
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in several processes, including extraction of mislocalized protein from mitochondrial outer membrane; learning or memory; and regulation of receptor internalization. Predicted to be located in mitochondrion; peroxisomal membrane; and postsynaptic membrane. Predicted to be active in glutamatergic synapse; mitochondrial outer membrane; and postsynapse. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 378.0), Muscle (RPKM 288.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atad1 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239957329..240023792, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (230544227..230610524, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (251234702..251386996, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485221 Neighboring gene U2 spliceosomal RNA Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Neighboring gene uncharacterized LOC134485222 Neighboring gene glutathione S-transferase P 1-like Neighboring gene phosphatase and tensin homolog Neighboring gene uncharacterized LOC102547905 Neighboring gene aldo-keto reductase family 1, member B8, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Zhang J, et al. Cell, 2011 Apr 15. PMID 21496646, Free PMC Article
    2. Functional identification of neuroprotective molecules. Dai C, et al. PLoS One, 2010 Nov 24. PMID 21124846, Free PMC Article
    3. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables membrane protein dislocase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extraction of mislocalized protein from mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extraction of mislocalized protein from mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extraction of mislocalized protein from mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor internalization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    outer mitochondrial transmembrane helix translocase
    Names
    ATPase family AAA domain-containing protein 1
    neuroprotective protein 6
    thorase
    NP_001030174.1
    XP_038936585.1
    XP_038936590.1
    XP_038936599.1
    XP_038936607.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035002.1 → NP_001030174.1  outer mitochondrial transmembrane helix translocase

      See identical proteins and their annotated locations for NP_001030174.1

      Status: PROVISIONAL

      Source sequence(s)
      BC094514
      UniProtKB/Swiss-Prot
      B3STU2, Q505J9
      UniProtKB/TrEMBL
      A6I109
      Related
      ENSRNOP00000014684.5, ENSRNOT00000014684.9
      Conserved Domains (2) summary
      pfam17862
      Location:282 → 321
      AAA_lid_3; AAA+ lid domain
      cd19520
      Location:92 → 257
      RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      239957329..240023792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080657.2 → XP_038936585.1  outer mitochondrial transmembrane helix translocase isoform X1

      UniProtKB/Swiss-Prot
      B3STU2, Q505J9
      UniProtKB/TrEMBL
      A6I109
      Conserved Domains (2) summary
      pfam17862
      Location:282 → 321
      AAA_lid_3; AAA+ lid domain
      cd19520
      Location:92 → 257
      RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

    2. XM_039080662.2 → XP_038936590.1  outer mitochondrial transmembrane helix translocase isoform X1

      UniProtKB/Swiss-Prot
      B3STU2, Q505J9
      UniProtKB/TrEMBL
      A6I109
      Conserved Domains (2) summary
      pfam17862
      Location:282 → 321
      AAA_lid_3; AAA+ lid domain
      cd19520
      Location:92 → 257
      RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

    3. XM_039080671.2 → XP_038936599.1  outer mitochondrial transmembrane helix translocase isoform X1

      UniProtKB/Swiss-Prot
      B3STU2, Q505J9
      UniProtKB/TrEMBL
      A6I109
      Conserved Domains (2) summary
      pfam17862
      Location:282 → 321
      AAA_lid_3; AAA+ lid domain
      cd19520
      Location:92 → 257
      RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains

    4. XM_039080679.2 → XP_038936607.1  outer mitochondrial transmembrane helix translocase isoform X2

      Conserved Domains (2) summary
      pfam17862
      Location:224 → 263
      AAA_lid_3; AAA+ lid domain
      cd19520
      Location:34 → 199
      RecA-like_ATAD1; ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q505J9.1 GenPept UniProtKB/Swiss-Prot:Q505J9

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