Abr ABR activator of RhoGEF and GTPase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Abrprovided by RGD
Full Name: ABR activator of RhoGEF and GTPaseprovided by RGD
Primary source: RGD:1306279
See related: EnsemblRapid:ENSRNOG00000056837 AllianceGenome:RGD:1306279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of blood vessel remodeling; and negative regulation of cellular extravasation. Predicted to act upstream of or within several processes, including negative regulation of macrophage migration; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 421.4), Spleen (RPKM 156.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (61760743..61959526, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (61262516..61461331, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (64565121..64657079, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

breakpoint cluster region and ABR have novel roles in the regulation of synaptic Rac1 signaling, synaptic plasticity, and learning and memory, and that excessive Rac1 activity negatively affects synaptic and cognitive functions
Title: Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

Submit: New GeneRIF Correction

General gene information

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Markers

d10mgh6 (e-PCR)
- UniSTS:120623

AU042359 (e-PCR)
- UniSTS:160122

BE104553 (e-PCR)
- UniSTS:245408

Abr (e-PCR), detects polymorphism
- UniSTS:140999

D10Mgh6 (e-PCR)
- UniSTS:240630

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of macrophage migration	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular extravasation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
acts_upstream_of neutrophil degranulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in Schaffer collateral - CA1 synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: active breakpoint cluster region-related protein

Names: ABR, RhoGEF and GTPase activating protein; active BCR-related; breakpoint cluster region protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105814.4 → NP_001099284.1 active breakpoint cluster region-related protein

See identical proteins and their annotated locations for NP_001099284.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

A0A0G2JTR4

UniProtKB/TrEMBL

A0A4X0W8E9, A6HGV7

Related

ENSRNOP00000085893.2, ENSRNOT00000098977.2

Conserved Domains (4) summary

cd08686
Location:506 → 626

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:92 → 282

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:645 → 840

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:277 → 460

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

61760743..61959526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085523.2 → XP_038941451.1 active breakpoint cluster region-related protein isoform X1

UniProtKB/TrEMBL

A0A8I6A3Q6

Related

ENSRNOP00000085287.1, ENSRNOT00000109843.2

Conserved Domains (5) summary

cd08686
Location:832 → 952

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:418 → 608

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:971 → 1166

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:603 → 786

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

pfam09036
Location:3 → 67

Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
XM_039085524.2 → XP_038941452.1 active breakpoint cluster region-related protein isoform X2

UniProtKB/TrEMBL

A0A4X0W8E9

Related

ENSRNOP00000068811.3, ENSRNOT00000080703.3

Conserved Domains (4) summary

cd08686
Location:563 → 683

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:149 → 339

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:702 → 897

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:334 → 517

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
XM_039085528.2 → XP_038941456.1 active breakpoint cluster region-related protein isoform X3

UniProtKB/TrEMBL

A0A4X0W8E9, A0A8I6A171

Related

ENSRNOP00000105867.1, ENSRNOT00000139836.1

Conserved Domains (4) summary

cd08686
Location:497 → 617

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:83 → 273

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:636 → 831

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:268 → 451

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
XM_039085531.2 → XP_038941459.1 active breakpoint cluster region-related protein isoform X5

UniProtKB/TrEMBL

A0A4X0W8E9

Related

ENSRNOP00000107867.1, ENSRNOT00000138045.1

Conserved Domains (4) summary

cd08686
Location:460 → 580

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:46 → 236

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:599 → 794

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:231 → 414

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
XM_039085527.2 → XP_038941455.1 active breakpoint cluster region-related protein isoform X3

UniProtKB/TrEMBL

A0A4X0W8E9, A0A8I6A171

Conserved Domains (4) summary

cd08686
Location:497 → 617

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:83 → 273

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:636 → 831

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:268 → 451

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
XM_039085530.2 → XP_038941458.1 active breakpoint cluster region-related protein isoform X5

UniProtKB/TrEMBL

A0A4X0W8E9

Conserved Domains (4) summary

cd08686
Location:460 → 580

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd00160
Location:46 → 236

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd04387
Location:599 → 794

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:231 → 414

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
XM_039085529.2 → XP_038941457.1 active breakpoint cluster region-related protein isoform X4

UniProtKB/TrEMBL

A0A0G2JZZ7, A0A4X0W8E9

Related

ENSRNOP00000071246.1, ENSRNOT00000084670.3
XM_039085532.2 → XP_038941460.1 active breakpoint cluster region-related protein isoform X6

UniProtKB/TrEMBL

A0A8I6GI56

Related

ENSRNOP00000090388.1, ENSRNOT00000105253.2

Conserved Domains (4) summary

cd08686
Location:288 → 408

C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein

cd04387
Location:427 → 622

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cd13366
Location:59 → 242

PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain

cl02571
Location:17 → 64

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
XM_039085533.2 → XP_038941461.1 active breakpoint cluster region-related protein isoform X7

Conserved Domains (2) summary

cd04387
Location:102 → 297

RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...

cl14603
Location:55 → 83

C2; C2 domain