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    Rnf43 ring finger protein 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf43provided by RGD
    Official Full Name
    ring finger protein 43provided by RGD
    Primary source
    RGD:1305204
    See related
    EnsemblRapid:ENSRNOG00000007606 AllianceGenome:RGD:1305204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305204
    Summary
    Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including Wnt receptor catabolic process; stem cell proliferation; and ubiquitin-dependent protein catabolic process. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 28.5), Kidney (RPKM 20.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf43 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72958744..73034540)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (72461508..72537301)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74956411..75028951)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor 5 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480847 Neighboring gene SPT4 homolog, DSIF elongation factor subunit Neighboring gene TSPO associated protein 1 Neighboring gene microRNA 142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Okuno K, et al. Exp Ther Med, 2011 Jan. PMID 22977472, Free PMC Article
    2. [Preliminary study of Peptide vaccine with UFT/LV as adjuvant setting for stage III colorectal cancer]. Okuno K, et al. Gan To Kagaku Ryoho, 2011 Nov. PMID 22202234
    3. [Clinical study of Peptide-cocktail vaccination with tegafur-uracil/leucovorin for advanced colorectal cancer]. Sugiura F, et al. Gan To Kagaku Ryoho, 2012 Nov. PMID 23267878
    4. Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. Gala MK, et al. Gastroenterology, 2014 Feb. PMID 24512911, Free PMC Article
    5. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Wang K, et al. Nat Genet, 2014 Jun. PMID 24816253

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Wnt receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF43
    NP_001129393.1
    XP_006247152.1
    XP_006247153.1
    XP_006247156.1
    XP_008766263.1
    XP_038941978.1
    XP_063125163.1
    XP_063125164.1
    XP_063125165.1
    XP_063125166.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135921.2 → NP_001129393.1  E3 ubiquitin-protein ligase RNF43 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AML0, A6HHU8
      Related
      ENSRNOP00000010296.6, ENSRNOT00000010296.7
      Conserved Domains (2) summary
      pfam13639
      Location:270 → 312
      zf-RING_2; Ring finger domain
      cl10459
      Location:87 → 174
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72958744..73034540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269093.1 → XP_063125163.1  E3 ubiquitin-protein ligase RNF43 isoform X1

      UniProtKB/TrEMBL
      A6HHU8

    2. XM_039086050.2 → XP_038941978.1  E3 ubiquitin-protein ligase RNF43 isoform X1

      UniProtKB/TrEMBL
      A6HHU8
      Conserved Domains (3) summary
      PRK14086
      Location:598 → 743
      dnaA; chromosomal replication initiator protein DnaA
      cd16798
      Location:270 → 316
      RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins
      pfam18212
      Location:85 → 187
      ZNRF_3_ecto; ZNRF-3 Ectodomain

    3. XM_006247090.5 → XP_006247152.1  E3 ubiquitin-protein ligase RNF43 isoform X1

      See identical proteins and their annotated locations for XP_006247152.1

      UniProtKB/TrEMBL
      A6HHU8
      Conserved Domains (3) summary
      PRK14086
      Location:598 → 743
      dnaA; chromosomal replication initiator protein DnaA
      cd16798
      Location:270 → 316
      RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins
      pfam18212
      Location:85 → 187
      ZNRF_3_ecto; ZNRF-3 Ectodomain

    4. XM_006247091.5 → XP_006247153.1  E3 ubiquitin-protein ligase RNF43 isoform X1

      See identical proteins and their annotated locations for XP_006247153.1

      UniProtKB/TrEMBL
      A6HHU8
      Conserved Domains (3) summary
      PRK14086
      Location:598 → 743
      dnaA; chromosomal replication initiator protein DnaA
      cd16798
      Location:270 → 316
      RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins
      pfam18212
      Location:85 → 187
      ZNRF_3_ecto; ZNRF-3 Ectodomain

    5. XM_063269094.1 → XP_063125164.1  E3 ubiquitin-protein ligase RNF43 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AML0, A6HHU8

    6. XM_063269095.1 → XP_063125165.1  E3 ubiquitin-protein ligase RNF43 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AML0, A6HHU8
      Related
      ENSRNOP00000095208.1, ENSRNOT00000105746.2

    7. XM_063269096.1 → XP_063125166.1  E3 ubiquitin-protein ligase RNF43 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AML0, A6HHU8

    8. XM_006247094.5 → XP_006247156.1  E3 ubiquitin-protein ligase RNF43 isoform X3

      See identical proteins and their annotated locations for XP_006247156.1

      UniProtKB/TrEMBL
      D3ZP81
      Conserved Domains (1) summary
      pfam13639
      Location:143 → 185
      zf-RING_2; Ring finger domain

    9. XM_008768041.4 → XP_008766263.1  E3 ubiquitin-protein ligase RNF43 isoform X3

      See identical proteins and their annotated locations for XP_008766263.1

      UniProtKB/TrEMBL
      D3ZP81
      Conserved Domains (1) summary
      pfam13639
      Location:143 → 185
      zf-RING_2; Ring finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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