Tac4 tachykinin precursor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tac4provided by RGD
Official Full Name: tachykinin precursor 4provided by RGD
Primary source: RGD:628842
See related: AllianceGenome:RGD:628842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppt-c
Summary: Predicted to enable receptor ligand activity; substance K receptor binding activity; and substance P receptor binding activity. Involved in detection of temperature stimulus involved in sensory perception of pain and positive regulation of sensory perception of pain. Located in extracellular space. Orthologous to human TAC4 (tachykinin precursor 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 8.1), Lung (RPKM 5.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80704640..80712972)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (80207824..80216156)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (83081168..83089487)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor
Title: Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.
Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-kappaB and p38 MAPK signaling pathways
Title: Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways.
These findings indicate that three amino acids, Ser, Thr and Arg at the 2nd, 4th and 5th positions of HK-1, respectively, regulate the induction of thermal hyperalgesia by HK-1.
Title: The amino-terminal region of hemokinin-1 regulates the induction of thermal hyperalgesia in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables substance K receptor binding	ISO Inferred from Sequence Orthology more info
enables substance P receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables substance P receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in detection of temperature stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tachykinin receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tachykinin-4

Names: preprotachykinin-C; tachykinin 4 (hemokinin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.