Cfap52 cilia and flagella associated protein 52 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfap52provided by RGD
Official Full Name: cilia and flagella associated protein 52provided by RGD
Primary source: RGD:1308151
See related: EnsemblRapid:ENSRNOG00000037718 AllianceGenome:RGD:1308151
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Usp43; Wdr16
Summary: Predicted to be involved in establishment of left/right asymmetry and flagellated sperm motility. Predicted to act upstream of or within several processes, including microtubule sliding; single fertilization; and spermatid development. Predicted to be located in 9+2 motile cilium and axonemal microtubule. Predicted to be active in axonemal B tubule inner sheath and sperm midpiece. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFAP52 (cilia and flagella associated protein 52). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 177.0), Lung (RPKM 44.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (53112692..53153844, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (52613761..52654922, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (54470834..54512157, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d10mgh24 (e-PCR)
- UniSTS:120619

RH130401 (e-PCR)
- UniSTS:213685

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in establishment of left/right asymmetry	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule sliding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in axonemal B tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info
is_active_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilia- and flagella-associated protein 52

Names: WD repeat domain 16; WD repeat-containing protein 16; ubiquitin specific peptidase 43; ubiquitin specific protease 43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100968.2 → NP_001094438.2 cilia- and flagella-associated protein 52

See identical proteins and their annotated locations for NP_001094438.2

Status: VALIDATED

Source sequence(s)

BC161799

UniProtKB/TrEMBL

A4K5G8, A6HFJ5, B1WBL5, F7ETN2

Related

ENSRNOP00000005066.3, ENSRNOT00000005066.6

Conserved Domains (3) summary

COG2319
Location:277 → 617

WD40; WD40 repeat [General function prediction only]

sd00039
Location:380 → 414

7WD40; WD40 repeat [structural motif]

cl02567
Location:346 → 615

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

53112692..53153844 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085974.2 → XP_038941902.1 cilia- and flagella-associated protein 52 isoform X1

Conserved Domains (3) summary

COG2319
Location:5 → 224

WD40; WD40 repeat [General function prediction only]

sd00039
Location:205 → 239

7WD40; WD40 repeat [structural motif]

cl29593
Location:171 → 440

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...