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    Gucy2d guanylate cyclase 2D, retinal [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gucy2dprovided by RGD
    Official Full Name
    guanylate cyclase 2D, retinalprovided by RGD
    Primary source
    RGD:620438
    See related
    EnsemblRapid:ENSRNOG00000007931 AllianceGenome:RGD:620438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gucy2e; RETGC-1
    Summary
    Enables guanylate cyclase activity and protein homodimerization activity. Involved in cGMP-mediated signaling. Located in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 3.6), Lung (RPKM 1.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gucy2d in Genome Data Viewer
    Location:
    10q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54453753..54478639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53954918..53975576, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55835695..55851235, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene arachidonate 15-lipoxygenase, type B Neighboring gene U6 spliceosomal RNA Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca(2+)-Dependent Cyclic GMP Synthesis. Wimberg H, et al. Front Mol Neurosci, 2018. PMID 30319355, Free PMC Article
    2. Clustering and frequency of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod dystrophies. Payne AM, et al. J Med Genet, 2001 Sep. PMID 11565546, Free PMC Article
    3. Two membrane forms of guanylyl cyclase found in the eye. Yang RB, et al. Proc Natl Acad Sci U S A, 1995 Jan 17. PMID 7831337, Free PMC Article
    4. The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator. Dizhoor AM, et al. Neuron, 1994 Jun. PMID 7912093
    5. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. Yang RB, et al. J Biol Chem, 1997 May 23. PMID 9153227

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in photoreceptor outer segment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinal guanylyl cyclase 1
    Names
    guanylate cyclase 2D, membrane (retina-specific)
    guanylate cyclase 2E
    guanylyl cyclase 2e
    guanylyl cyclase GC-E
    NP_077356.1
    XP_038942841.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024380.1 → NP_077356.1  retinal guanylyl cyclase 1 precursor

      See identical proteins and their annotated locations for NP_077356.1

      Status: PROVISIONAL

      Source sequence(s)
      L36029
      UniProtKB/Swiss-Prot
      P51840
      UniProtKB/TrEMBL
      A6HFP3, V9GZ79
      Related
      ENSRNOP00000010790.5, ENSRNOT00000010790.6
      Conserved Domains (4) summary
      smart00044
      Location:848 → 1039
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:540 → 814
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      cd06371
      Location:58 → 434
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:823 → 868
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54453753..54478639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086913.2 → XP_038942841.1  retinal guanylyl cyclase 1 isoform X1

      UniProtKB/Swiss-Prot
      P51840
      UniProtKB/TrEMBL
      A6HFP3, V9GZ79
      Conserved Domains (4) summary
      smart00044
      Location:848 → 1039
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14043
      Location:540 → 814
      PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
      cd06371
      Location:58 → 434
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:823 → 868
      HNOBA; Heme NO binding associated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51840.1 GenPept UniProtKB/Swiss-Prot:P51840

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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