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    Utp18 UTP18 small subunit processome component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Utp18provided by RGD
    Official Full Name
    UTP18 small subunit processome componentprovided by RGD
    Primary source
    RGD:1309957
    See related
    EnsemblRapid:ENSRNOG00000002644 AllianceGenome:RGD:1309957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr50; RGD1309957
    Summary
    Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 118.6), Thymus (RPKM 100.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Utp18 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79308785..79336241, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (78811879..78839338, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81560929..81588156, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10 like 2 Neighboring gene uncharacterized LOC120095281 Neighboring gene mbt domain containing 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Yokoyama A, et al. Mol Cell Biol, 2004 Jul. PMID 15199122, Free PMC Article
    2. Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment. Lee NH, et al. Proc Natl Acad Sci U S A, 1995 Aug 29. PMID 7667285, Free PMC Article
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U3 small nucleolar RNA-associated protein 18 homolog
    Names
    UTP18 small subunit (SSU) processome component
    UTP18, small subunit (SSU) processome component, homolog
    WD repeat domain 50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135039.2 → NP_001128511.1  U3 small nucleolar RNA-associated protein 18 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZNH2
      Related
      ENSRNOP00000080215.1, ENSRNOT00000112449.2
      Conserved Domains (2) summary
      COG2319
      Location:211 → 541
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:244 → 284
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      79308785..79336241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086056.1 → XP_038941984.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X1

      UniProtKB/TrEMBL
      D3ZNH2
      Related
      ENSRNOP00000003582.9, ENSRNOT00000003582.9
      Conserved Domains (2) summary
      COG2319
      Location:211 → 541
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:244 → 284
      7WD40; WD40 repeat [structural motif]

    2. XM_063269108.1 → XP_063125178.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X3

      UniProtKB/TrEMBL
      A6HI29

    3. XM_063269107.1 → XP_063125177.1  U3 small nucleolar RNA-associated protein 18 homolog isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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