U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmem50b transmembrane protein 50B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360698, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmem50bprovided by RGD
    Official Full Name
    transmembrane protein 50Bprovided by RGD
    Primary source
    RGD:1307561
    See related
    EnsemblRapid:ENSRNOG00000002028 AllianceGenome:RGD:1307561
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307561
    Summary
    Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Predicted to be located in endoplasmic reticulum. Orthologous to human TMEM50B (transmembrane protein 50B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 297.6), Brain (RPKM 296.3) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmem50b in Genome Data Viewer
    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44290805..44323650, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30804835..30837675, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31719441..31752276, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS7-like Neighboring gene uncharacterized LOC134481058 Neighboring gene interferon gamma receptor 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain. Moldrich RX, et al. Neuroscience, 2008 Jul 17. PMID 18541381
    2. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tmem50b is a developmentally-regulated intracellular ER and Golgi apparatus membrane protein that may prove important for correct brain development through functions associated with precursor cells and glia.
      Title: Transmembrane protein 50b (C21orf4), a candidate for Down syndrome neurophenotypes, encodes an intracellular membrane protein expressed in the rodent brain.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC109374

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane protein 50B

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025014.1 → NP_001020185.1  transmembrane protein 50B

      See identical proteins and their annotated locations for NP_001020185.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091349
      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Related
      ENSRNOP00000002775.5, ENSRNOT00000002775.7
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44290805..44323650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270610.1 → XP_063126680.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6

    2. XM_017598025.3 → XP_017453514.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    3. XM_006248066.5 → XP_006248128.1  transmembrane protein 50B isoform X1

      See identical proteins and their annotated locations for XP_006248128.1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    4. XM_006248067.5 → XP_006248129.1  transmembrane protein 50B isoform X1

      See identical proteins and their annotated locations for XP_006248129.1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    5. XM_063270609.1 → XP_063126679.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6

    6. XM_006248068.5 → XP_006248130.1  transmembrane protein 50B isoform X1

      See identical proteins and their annotated locations for XP_006248130.1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    7. XM_039088458.2 → XP_038944386.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
      Conserved Domains (1) summary
      pfam05255
      Location:9 → 157
      UPF0220; Uncharacterized protein family (UPF0220)

    8. XM_063270612.1 → XP_063126682.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6

    9. XM_063270611.1 → XP_063126681.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6

    10. XM_063270613.1 → XP_063126683.1  transmembrane protein 50B isoform X1

      UniProtKB/TrEMBL
      A6JLG5, A6JLG6, Q5BJS6
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools