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    Tm4sf19 transmembrane 4 L six family member 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm4sf19provided by RGD
    Official Full Name
    transmembrane 4 L six family member 19provided by RGD
    Primary source
    RGD:1560486
    See related
    EnsemblRapid:ENSRNOG00000001757 AllianceGenome:RGD:1560486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560486
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of osteoclast differentiation. Predicted to be located in actin cytoskeleton and filopodium. Predicted to be active in membrane. Orthologous to human TM4SF19 (transmembrane 4 L six family member 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 7.6), Lung (RPKM 5.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tm4sf19 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81876714..81899603, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68372945..68386192, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71607735..71619108, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 1A, choline Neighboring gene uncharacterized LOC134481088 Neighboring gene dynein light chain Tctex-type 2B Neighboring gene UBX domain protein 7 Neighboring gene UBX domain protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 4 L6 family member 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105873.1 → NP_001099343.1  transmembrane 4 L6 family member 19

      See identical proteins and their annotated locations for NP_001099343.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473967
      UniProtKB/TrEMBL
      A6IRS1, D4ADI7
      Conserved Domains (1) summary
      pfam05805
      Location:10 → 204
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81876714..81899603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088113.2 → XP_038944041.1  transmembrane 4 L6 family member 19 isoform X1

      UniProtKB/TrEMBL
      A6IRS1, D4ADI7
      Conserved Domains (1) summary
      pfam05805
      Location:10 → 204
      L6_membrane; L6 membrane protein

    2. XM_039088115.2 → XP_038944043.2  transmembrane 4 L6 family member 19 isoform X2

    3. XM_039088111.2 → XP_038944039.1  transmembrane 4 L6 family member 19 isoform X1

      UniProtKB/TrEMBL
      A6IRS1, D4ADI7
      Related
      ENSRNOP00000002396.4, ENSRNOT00000002396.7
      Conserved Domains (1) summary
      pfam05805
      Location:10 → 204
      L6_membrane; L6 membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version

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