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    Tssk1b testis-specific serine kinase 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tssk1bprovided by RGD
    Official Full Name
    testis-specific serine kinase 1Bprovided by RGD
    Primary source
    RGD:1307352
    See related
    EnsemblRapid:ENSRNOG00000068894 AllianceGenome:RGD:1307352
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tssk1; Stk22a
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and spermatid development. Predicted to be located in motile cilium. Orthologous to human TSSK1B (testis specific serine kinase 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Tssk1b in Genome Data Viewer
    Location:
    11q23
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96595216..96596639, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83090930..83092353, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87239410..87240833, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481038 Neighboring gene goosecoid homeobox 2 Neighboring gene ess-2 splicing factor homolog Neighboring gene testis-specific serine kinase 2 Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene carbonic anhydrase 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. Zhang L, et al. J Med Chem, 2009 Jul 23. PMID 19530700
    2. Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18533145, Free PMC Article
    3. Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Li Y, et al. Mol Hum Reprod, 2011 Jan. PMID 20729278, Free PMC Article
    4. Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility. Jha KN, et al. J Biol Chem, 2013 Jun 7. PMID 23599433, Free PMC Article
    5. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. Jaleel M, et al. FEBS Lett, 2005 Feb 28. PMID 15733851

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine/threonine-protein kinase 1
    Names
    serine/threonine kinase 22A (spermiogenesis associated)
    spermiogenesis associated
    testis-specific serine kinase 1
    NP_001011900.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011900.1 → NP_001011900.1  testis-specific serine/threonine-protein kinase 1

      See identical proteins and their annotated locations for NP_001011900.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083661
      UniProtKB/TrEMBL
      A0A8I6AN48, Q6V9Y2
      Related
      ENSRNOP00000105960.1, ENSRNOT00000151516.1
      Conserved Domains (2) summary
      smart00220
      Location:12 → 272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14165
      Location:10 → 271
      STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96595216..96596639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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