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    Cdk8 cyclin-dependent kinase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk8provided by RGD
    Official Full Name
    cyclin-dependent kinase 8provided by RGD
    Primary source
    RGD:1560888
    See related
    EnsemblRapid:ENSRNOG00000039819 AllianceGenome:RGD:1560888
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560888
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in negative regulation of triglyceride metabolic process and protein ubiquitination. Part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 121.4), Kidney (RPKM 108.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk8 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13851024..13919017, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8737198..8805026, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10496273..10561335, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene WASP family member 3 Neighboring gene uncharacterized LOC120095890 Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene uncharacterized LOC120095930 Neighboring gene ring finger protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association between CDK8 gene polymorphisms and dilated cardiomyopathy in a Chinese Han population. Zhang R, et al. Cardiovasc Diagn Ther, 2021 Oct. PMID 34815954, Free PMC Article
    2. MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8. Dou P, et al. J Biosci, 2021. PMID 33737500
    3. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Porter DC, et al. Proc Natl Acad Sci U S A, 2012 Aug 21. PMID 22869755, Free PMC Article
    4. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, et al. Chem Rev, 2013 Nov 13. PMID 23837720
    5. Updating the RNA polymerase CTD code: adding gene-specific layers. Egloff S, et al. Trends Genet, 2012 Jul. PMID 22622228

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8.
      Title: MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2 cells via targeting CDK8.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CKM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 8
    NP_001102531.1
    XP_038945612.1
    XP_038945613.1
    XP_038945614.1
    XP_038945615.1
    XP_038945616.1
    XP_038945618.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109061.1 → NP_001102531.1  cyclin-dependent kinase 8

      See identical proteins and their annotated locations for NP_001102531.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/TrEMBL
      A0A8I5ZYM4, A6K1D1
      Related
      ENSRNOP00000081852.2, ENSRNOT00000092276.3
      Conserved Domains (1) summary
      cd07868
      Location:3 → 335
      STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      13851024..13919017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089687.2 → XP_038945615.1  cyclin-dependent kinase 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZVW8, A0A8I5ZYM4
      Conserved Domains (1) summary
      cl21453
      Location:3 → 287
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039089686.2 → XP_038945614.1  cyclin-dependent kinase 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZYM4
      Conserved Domains (1) summary
      cl21453
      Location:3 → 325
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039089685.2 → XP_038945613.1  cyclin-dependent kinase 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYM4
      Conserved Domains (1) summary
      cl21453
      Location:3 → 330
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039089684.2 → XP_038945612.1  cyclin-dependent kinase 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYM4
      Conserved Domains (1) summary
      cd07868
      Location:3 → 335
      STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

    5. XM_039089688.2 → XP_038945616.1  cyclin-dependent kinase 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZYM4
      Conserved Domains (1) summary
      cl21453
      Location:1 → 275
      PKc_like; Protein Kinases, catalytic domain

    6. XM_039089690.2 → XP_038945618.1  cyclin-dependent kinase 8 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:3 → 228
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_010056410.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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