Zscan21 zinc finger and SCAN domain containing 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zscan21provided by RGD
Official Full Name: zinc finger and SCAN domain containing 21provided by RGD
Primary source: RGD:1309981
See related: EnsemblRapid:ENSRNOG00000039234 AllianceGenome:RGD:1309981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zipro1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in male meiosis I; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZSCAN21 (zinc finger and SCAN domain containing 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 79.0), Lung (RPKM 77.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (22112204..22142506)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (16998496..17024167)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19262977..19277913)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the unaltered SNCA levels observed following ZSCAN21 down-regulation in the rat brain, possibly due to compensatory mechanisms, imply that ZSCAN21 is not a master regulator of SNCA in vivo.
Title: Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo.
Transcription factor zinc finger and SCAN domain containing (ZSCAN)21, which binds to a site within intron 1, is a key regulator of alpha-synuclein transcription in neuronal cells.
Title: Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219.
Zipro1 is a good candidate for a transcription factor involved in activation of non-myelinating cervical sympathetic trunk.
Title: Induction of zinc-finger proliferation 1 expression in non-myelinating Schwann cells after denervation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in male meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and SCAN domain-containing protein 21

Names: zinc finger proliferation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012021.2 → NP_001012021.1 zinc finger and SCAN domain-containing protein 21

See identical proteins and their annotated locations for NP_001012021.1

Status: VALIDATED

Source sequence(s)

BC079435, BG379149, FM121830

UniProtKB/TrEMBL

Q6AXN8

Related

ENSRNOP00000001810.4, ENSRNOT00000001810.7

Conserved Domains (4) summary

smart00431
Location:119 → 229

SCAN; leucine rich region

COG5048
Location:338 → 534

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:471 → 491

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:527 → 547

zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

22112204..22142506

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089408.2 → XP_038945336.1 zinc finger and SCAN domain-containing protein 21 isoform X4

Conserved Domains (1) summary

smart00431
Location:119 → 229

SCAN; leucine rich region
XM_039089407.2 → XP_038945335.1 zinc finger and SCAN domain-containing protein 21 isoform X3

Conserved Domains (1) summary

smart00431
Location:119 → 229

SCAN; leucine rich region
XM_063271277.1 → XP_063127347.1 zinc finger and SCAN domain-containing protein 21 isoform X4
XM_063271275.1 → XP_063127345.1 zinc finger and SCAN domain-containing protein 21 isoform X2
XM_063271276.1 → XP_063127346.1 zinc finger and SCAN domain-containing protein 21 isoform X3
XM_039089402.2 → XP_038945330.1 zinc finger and SCAN domain-containing protein 21 isoform X1

UniProtKB/TrEMBL

Q6AXN8

Conserved Domains (4) summary

smart00431
Location:119 → 229

SCAN; leucine rich region

COG5048
Location:338 → 534

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:471 → 491

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:527 → 547

zf-C2H2; Zinc finger, C2H2 type