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    Pitpnm2 phosphatidylinositol transfer protein, membrane-associated 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304474, updated on 9-Dec-2024

    Summary

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    Symbol
    Pitpnm2provided by RGD
    Full Name
    phosphatidylinositol transfer protein, membrane-associated 2provided by RGD
    Primary source
    RGD:1310867
    See related
    EnsemblRapid:ENSRNOG00000029260 AllianceGenome:RGD:1310867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including phospholipid binding activity; phospholipid transporter activity; and receptor tyrosine kinase binding activity. Predicted to be involved in intermembrane lipid transfer and phospholipid transport. Located in cell body. Orthologous to human PITPNM2 (phosphatidylinositol transfer protein membrane associated 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 89.7), Lung (RPKM 75.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pitpnm2 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38008399..38140046)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32347455..32479103)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37805332..37903856)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mitochondrial translation release factor in rescue Neighboring gene M-phase phosphoprotein 9 Neighboring gene uncharacterized LOC134481294 Neighboring gene ARF like GTPase 6 interacting protein 4 Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. Lu C, et al. J Neurosci, 1999 Sep 1. PMID 10460238, Free PMC Article
    2. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, et al. Mol Cell Biol, 1999 Mar. PMID 10022914, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189186

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated phosphatidylinositol transfer protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107139.1 → NP_001100609.1  membrane-associated phosphatidylinositol transfer protein 2

      See identical proteins and their annotated locations for NP_001100609.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A0A0G2JW50, A6J110
      Conserved Domains (3) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1040 → 1171
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:704 → 894
      DDHD; DDHD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38008399..38140046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089445.2 → XP_038945373.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    2. XM_039089453.2 → XP_038945381.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW50
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1094 → 1225
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:991 → 1140
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 948
      DDHD; DDHD domain

    3. XM_063271306.1 → XP_063127376.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JW50, A6J110

    4. XM_063271308.1 → XP_063127378.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X5

    5. XM_063271309.1 → XP_063127379.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X6

    6. XM_039089447.2 → XP_038945375.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    7. XM_063271304.1 → XP_063127374.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW50
      Related
      ENSRNOP00000069743.3, ENSRNOT00000091084.3

    8. XM_039089450.2 → XP_038945378.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    9. XM_039089448.2 → XP_038945376.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    10. XM_063271312.1 → XP_063127382.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JXL0, A0A9K3Y8B5, B5DF34
      Related
      ENSRNOP00000070314.2, ENSRNOT00000084587.3

    11. XM_063271311.1 → XP_063127381.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JXL0, A0A9K3Y8B5, B5DF34

    12. XM_039089449.2 → XP_038945377.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    13. XM_039089446.2 → XP_038945374.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Related
      ENSRNOP00000095932.1, ENSRNOT00000110818.2
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    14. XM_063271310.1 → XP_063127380.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JXL0, A0A9K3Y8B5, B5DF34

    15. XM_063271305.1 → XP_063127375.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JW50, F1LXD6
      Related
      ENSRNOP00000041143.5, ENSRNOT00000048528.6

    16. XM_063271303.1 → XP_063127373.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW50

    17. XM_063271307.1 → XP_063127377.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JW50, A6J110

    18. XM_039089451.2 → XP_038945379.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW50, A0A8I6AUE0
      Conserved Domains (4) summary
      cd08889
      Location:1 → 258
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:1144 → 1275
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      COG5083
      Location:1041 → 1190
      SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
      pfam02862
      Location:704 → 998
      DDHD; DDHD domain

    19. XM_063271313.1 → XP_063127383.1  membrane-associated phosphatidylinositol transfer protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JXL0, A0A9K3Y8B5, B5DF34
    Nucleotide Protein Strain
    Heading Accession and Version

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