Ccl25 C-C motif chemokine ligand 25 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccl25provided by RGD
Official Full Name: C-C motif chemokine ligand 25provided by RGD
Primary source: RGD:1305530
See related: EnsemblRapid:ENSRNOG00000028531 AllianceGenome:RGD:1305530
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CCR10 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including eosinophil chemotaxis; positive regulation of cell-matrix adhesion; and regulation of cell migration. Predicted to act upstream of or within chemotaxis; leukocyte migration; and lymphoid lineage cell migration. Predicted to be active in extracellular space. Orthologous to human CCL25 (C-C motif chemokine ligand 25). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 722.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (7505231..7514402)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (2707398..2716571)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (2429492..2438928, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

presence of a mechanism by which gammadelta + T cells are increased in the intestinal villi, through different signaling path ways mediated by CCl25 and IL-7
Title: Importance of CCL25 in the attraction of T cells and the role of IL-7 on the signaling pathways in intestinal epithelial cells.
Thymus-expressed TECK chemokine promotes survival of serum-deprived PC12 cells through its receptor CCR9 via the phosphatidylinositol 3-kinase (PI3K) pathway.
Title: Thymus-expressed chemokine promotes survival of PC12 cells via PI3K pathway.
bile may contribute to high expression levels of TECK/CCL25 mRNA in the small intestine.
Title: Decreased expression of intestinal chemokine TECK/CCL25 in experimental obstructive jaundice and its reversal following internal biliary drainage.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR10 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphoid lineage cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-C motif chemokine 25

Names: chemokine (C-C motif) ligand 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037203.1 → NP_001032280.1 C-C motif chemokine 25 precursor

See identical proteins and their annotated locations for NP_001032280.1

Status: PROVISIONAL

Source sequence(s)

BC107945

UniProtKB/TrEMBL

A0A8I6AS46, A6KQ79, F7F2H8, Q32PX4

Related

ENSRNOP00000037785.4, ENSRNOT00000037059.6

Conserved Domains (1) summary

cl00134
Location:28 → 90

Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...