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    Caln1 calneuron 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caln1provided by RGD
    Official Full Name
    calneuron 1provided by RGD
    Primary source
    RGD:1305843
    See related
    EnsemblRapid:ENSRNOG00000080098 AllianceGenome:RGD:1305843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in trans-Golgi network membrane. Orthologous to human CALN1 (calneuron 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 289.5), Brain (RPKM 120.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Caln1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (31447964..31939847, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (25811743..26303670, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (29307117..29796996, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 17 Neighboring gene uncharacterized LOC102550645 Neighboring gene transfer RNA serine (anticodon AGA) 21 Neighboring gene uncharacterized LOC134481284 Neighboring gene interferon induced transmembrane protein 1, pseudogene 2 Neighboring gene tRNA-yW synthesizing protein 1 homolog Neighboring gene Sbds, ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Calneuron I inhibits Ca(2+) channel activity in bovine chromaffin cells. Shih PY, et al. Biochem Biophys Res Commun, 2009 Oct 23. PMID 19682431
    2. Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain. Hradsky J, et al. J Histochem Cytochem, 2015 Oct. PMID 26116628, Free PMC Article
    3. Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. Mikhaylova M, et al. Proc Natl Acad Sci U S A, 2009 Jun 2. PMID 19458041, Free PMC Article
    4. Neuronal Ca2+ signaling via caldendrin and calneurons. Mikhaylova M, et al. Biochim Biophys Acta, 2006 Nov. PMID 17055077
    5. Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy. Hisamitsu T, et al. Mol Cell Biol, 2012 Aug. PMID 22688515, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent.
      Title: Alternative splicing, expression and cellular localization of Calneuron-1 in the rat and human brain.
    2. NHE1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy
      Title: Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.
    3. These results suggest that CalnI attenuates Ca(2+) channel activity and that its subcellular localization is important for this effect.
      Title: Calneuron I inhibits Ca(2+) channel activity in bovine chromaffin cells.
    4. calneuron-1 and calneuron-2 physically associate with PI-4Kbeta, inhibit the enzyme profoundly at resting and low calcium levels, and negatively interfere with Golgi-to-plasma membrane trafficking.
      Title: Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.
    5. Calneurons have a different EF-hand organization than other calcium sensor proteins, are prominently expressed in neurons and will presumably bind Ca2+ with higher affinity than caldendrin.
      Title: Neuronal Ca2+ signaling via caldendrin and calneurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding protein 8
    Names
    caBP8
    calneuron I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077201.3 → NP_001070669.1  calcium-binding protein 8

      See identical proteins and their annotated locations for NP_001070669.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q06BI2, Q06BI3
      Conserved Domains (3) summary
      cd00051
      Location:82 → 143
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd15899
      Location:82 → 109
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:65 → 189
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      31447964..31939847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598405.3 → XP_017453894.1  calcium-binding protein 8 isoform X1

      UniProtKB/TrEMBL
      A6J0L7
      Related
      ENSRNOP00000099195.1, ENSRNOT00000164359.1
      Conserved Domains (1) summary
      PTZ00184
      Location:106 → 216
      PTZ00184; calmodulin; Provisional

    2. XM_063271556.1 → XP_063127626.1  calcium-binding protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q06BI2, Q06BI3

    3. XM_063271555.1 → XP_063127625.1  calcium-binding protein 8 isoform X1

      UniProtKB/TrEMBL
      A6J0L7

    4. XM_063271559.1 → XP_063127629.1  calcium-binding protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q06BI2, Q06BI3

    5. XM_039089627.2 → XP_038945555.1  calcium-binding protein 8 isoform X1

      UniProtKB/TrEMBL
      A6J0L7
      Conserved Domains (1) summary
      PTZ00184
      Location:106 → 216
      PTZ00184; calmodulin; Provisional

    6. XM_063271558.1 → XP_063127628.1  calcium-binding protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q06BI2, Q06BI3

    7. XM_017598406.3 → XP_017453895.1  calcium-binding protein 8 isoform X1

      UniProtKB/TrEMBL
      A6J0L7
      Conserved Domains (1) summary
      PTZ00184
      Location:106 → 216
      PTZ00184; calmodulin; Provisional

    8. XM_063271557.1 → XP_063127627.1  calcium-binding protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q06BI2, Q06BI3

    9. XM_039089628.2 → XP_038945556.1  calcium-binding protein 8 isoform X2

      UniProtKB/Swiss-Prot
      Q06BI2, Q06BI3
      Conserved Domains (3) summary
      cd00051
      Location:82 → 143
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd15899
      Location:82 → 109
      EFh_CREC; EF-hand motif [structural motif]
      cl25354
      Location:65 → 189
      EFh_CREC; EF-hand, calcium binding motif, found in CREC-EF hand family

    10. XM_017598407.3 → XP_017453896.1  calcium-binding protein 8 isoform X1

      UniProtKB/TrEMBL
      A6J0L7
      Conserved Domains (1) summary
      PTZ00184
      Location:106 → 216
      PTZ00184; calmodulin; Provisional

    11. XM_039089631.2 → XP_038945559.1  calcium-binding protein 8 isoform X3

      UniProtKB/TrEMBL
      A6J0L8
      Related
      ENSRNOP00000108139.1, ENSRNOT00000137173.1
      Conserved Domains (1) summary
      PTZ00184
      Location:32 → 142
      PTZ00184; calmodulin; Provisional

    12. XM_006249243.5 → XP_006249305.1  calcium-binding protein 8 isoform X3

      See identical proteins and their annotated locations for XP_006249305.1

      UniProtKB/TrEMBL
      A6J0L8
      Conserved Domains (1) summary
      PTZ00184
      Location:32 → 142
      PTZ00184; calmodulin; Provisional

    13. XM_063271560.1 → XP_063127630.1  calcium-binding protein 8 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06BI3.2 GenPept UniProtKB/Swiss-Prot:Q06BI3

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