Dao D-amino-acid oxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Daoprovided by RGD
Official Full Name: D-amino-acid oxidaseprovided by RGD
Primary source: RGD:621138
See related: EnsemblRapid:ENSRNOG00000054962 AllianceGenome:RGD:621138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dao1
Summary: Predicted to enable FAD binding activity; identical protein binding activity; and oxidoreductase activity, acting on the CH-NH2 group of donors. Predicted to be involved in several processes, including alpha-amino acid catabolic process; dopamine biosynthetic process; and neutrophil-mediated killing of gram-negative bacterium. Predicted to act upstream of or within L-leucine metabolic process. Located in peroxisomal matrix and presynaptic active zone. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human DAO (D-amino acid oxidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 3961.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (48252900..48275964, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (42592342..42613046, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (48353691..48373647, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of D-amino acid oxidase activity in rat kidney using a D-kynurenine derivative, 6-methylthio-D-kynurenine: An in vivo microdialysis study.
Title: Evaluation of D-amino acid oxidase activity in rat kidney using a D-kynurenine derivative, 6-methylthio-D-kynurenine: An in vivo microdialysis study.
Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.
Title: Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.
d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats.
Title: d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats.
Plasma DAO activity decreases in response to severe intestinal mucosal injury after 5-FU treatment.
Title: Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats.
Its toxic effect on motor neurons can be mediated by expression in motor neurons and it promotes autophagy.
Title: Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine.
The study showed that the operation of renal ischemia resulted in a 45.49 +/- 8.30% (n = 8) decrease in the DAAO-induced consumption of substrate, indicating a sharp decrease in renal DAAO activity following this acute renal injury.
Title: Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis.
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Title: D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase
Title: Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase.
results suggest that an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism, may be a potential therapeutic target for schizophrenia
Title: Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain.
These results suggest that the TAA repeats are important for expression of the D-amino-acid oxidase gene.
Title: Mutant rat strain lacking D-amino-acid oxidase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-amino-acid dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables D-amino-acid oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-amino-acid oxidase activity	IEA Inferred from Electronic Annotation more info
enables D-amino-acid oxidase activity	ISO Inferred from Sequence Orthology more info
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables glycine oxidase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in D-alanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-alanine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in D-amino acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in D-amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in D-serine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-serine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in D-serine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-leucine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in digestion	ISO Inferred from Sequence Orthology more info
involved_in digestion	ISS Inferred from Sequence or Structural Similarity more info
involved_in dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dopamine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in killing by host of symbiont cells	ISO Inferred from Sequence Orthology more info
involved_in neutrophil-mediated killing of gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in neutrophil-mediated killing of gram-negative bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in proline catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: D-amino-acid oxidase

Names: D-amino acid oxidase 1; DAAO; DAMOX

NP_446078.1

EC 1.4.3.3

XP_038944931.1

EC 1.4.3.3

XP_063127050.1

EC 1.4.3.3

XP_063127051.1

EC 1.4.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053626.1 → NP_446078.1 D-amino-acid oxidase

See identical proteins and their annotated locations for NP_446078.1

Status: PROVISIONAL

Source sequence(s)

AB003400

UniProtKB/Swiss-Prot

O35078

Related

ENSRNOP00000079300.1, ENSRNOT00000094356.2

Conserved Domains (1) summary

pfam01266
Location:2 → 328

DAO; FAD dependent oxidoreductase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

48252900..48275964 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270980.1 → XP_063127050.1 D-amino-acid oxidase isoform X1

UniProtKB/Swiss-Prot

O35078
XM_039089003.2 → XP_038944931.1 D-amino-acid oxidase isoform X1

UniProtKB/Swiss-Prot

O35078

Conserved Domains (1) summary

pfam01266
Location:2 → 328

DAO; FAD dependent oxidoreductase
XM_063270981.1 → XP_063127051.1 D-amino-acid oxidase isoform X1

UniProtKB/Swiss-Prot

O35078