Clasp1 cytoplasmic linker associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clasp1provided by RGD
Official Full Name: cytoplasmic linker associated protein 1provided by RGD
Primary source: RGD:1310970
See related: EnsemblRapid:ENSRNOG00000002376 AllianceGenome:RGD:1310970
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dystroglycan binding activity; kinetochore binding activity; and microtubule plus-end binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; negative regulation of cytoskeleton organization; and positive regulation of extracellular matrix organization. Predicted to act upstream of or within cell division; establishment of spindle orientation; and negative regulation of microtubule depolymerization. Located in kinetochore. Orthologous to human CLASP1 (cytoplasmic linker associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 196.2), Muscle (RPKM 179.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q11

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (32046362..32267954)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (29493554..29715151)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (34365038..34584651)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes.
Title: Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner.

Submit: New GeneRIF Correction

General gene information

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Markers

d13rat110 (e-PCR)
- UniSTS:120881

d13rat14 (e-PCR)
- UniSTS:120896

AU048339 (e-PCR)
- UniSTS:109633

UniSTS:234193 (e-PCR)
- UniSTS:234193

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables kinetochore binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinetochore binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell division	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in vesicle targeting	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in basal cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in centrosomal corona	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cortical microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CLIP-associating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427589.1 → NP_001414518.1 CLIP-associating protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6AEZ5

Related

ENSRNOP00000091698.2, ENSRNOT00000099252.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

32046362..32267954

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272238.1 → XP_063128308.1 CLIP-associating protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AEZ5
XM_063272254.1 → XP_063128324.1 CLIP-associating protein 1 isoform X16

UniProtKB/TrEMBL

F1LNR0
XM_063272256.1 → XP_063128326.1 CLIP-associating protein 1 isoform X18

UniProtKB/TrEMBL

F1LNR0
XM_063272274.1 → XP_063128344.1 CLIP-associating protein 1 isoform X39

UniProtKB/TrEMBL

F1LNR0
XM_063272239.1 → XP_063128309.1 CLIP-associating protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AEZ5
XM_063272240.1 → XP_063128310.1 CLIP-associating protein 1 isoform X3

UniProtKB/TrEMBL

A6K7W0
XM_063272257.1 → XP_063128327.1 CLIP-associating protein 1 isoform X20

UniProtKB/TrEMBL

A0A1B0GWM1
XM_063272248.1 → XP_063128318.1 CLIP-associating protein 1 isoform X11

UniProtKB/TrEMBL

A0A1B0GWM1
XM_039091269.2 → XP_038947197.1 CLIP-associating protein 1 isoform X22

UniProtKB/TrEMBL

A0A1B0GWM1

Related

ENSRNOP00000075946.3, ENSRNOT00000093066.3

Conserved Domains (3) summary

sd00044
Location:93 → 120

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:324 → 537

CLASP_N; CLASP N terminal
XM_063272251.1 → XP_063128321.1 CLIP-associating protein 1 isoform X13

UniProtKB/TrEMBL

A0A1B0GWM1
XM_063272259.1 → XP_063128329.1 CLIP-associating protein 1 isoform X24

UniProtKB/TrEMBL

A0A1B0GWM1, F1LNR1
XM_039091273.2 → XP_038947201.1 CLIP-associating protein 1 isoform X23

UniProtKB/TrEMBL

A0A8I5ZL32

Related

ENSRNOP00000076002.2, ENSRNOT00000093127.3

Conserved Domains (3) summary

sd00044
Location:93 → 120

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:324 → 537

CLASP_N; CLASP N terminal
XM_063272241.1 → XP_063128311.1 CLIP-associating protein 1 isoform X4

UniProtKB/TrEMBL

F1LNQ9
XM_063272260.1 → XP_063128330.1 CLIP-associating protein 1 isoform X25

UniProtKB/TrEMBL

F1LNQ9
XM_063272264.1 → XP_063128334.1 CLIP-associating protein 1 isoform X29

UniProtKB/TrEMBL

F1LNR0
XM_063272242.1 → XP_063128312.1 CLIP-associating protein 1 isoform X5

UniProtKB/TrEMBL

F1LNQ9
XM_063272261.1 → XP_063128331.1 CLIP-associating protein 1 isoform X26

UniProtKB/TrEMBL

F1LNQ9
XM_063272244.1 → XP_063128314.1 CLIP-associating protein 1 isoform X7

UniProtKB/TrEMBL

F1LNQ9
XM_063272262.1 → XP_063128332.1 CLIP-associating protein 1 isoform X27

UniProtKB/TrEMBL

F1LNQ9

Related

ENSRNOP00000069110.2, ENSRNOT00000086641.3
XM_039091263.2 → XP_038947191.1 CLIP-associating protein 1 isoform X19

UniProtKB/TrEMBL

F1LNR0

Conserved Domains (3) summary

sd00044
Location:93 → 120

HEAT; HEAT repeat [structural motif]

pfam02985
Location:168 → 198

HEAT; HEAT repeat

pfam12348
Location:324 → 537

CLASP_N; CLASP N terminal
XM_063272245.1 → XP_063128315.1 CLIP-associating protein 1 isoform X8

UniProtKB/TrEMBL

F1LNQ9
XM_063272263.1 → XP_063128333.1 CLIP-associating protein 1 isoform X28

UniProtKB/TrEMBL

F1LNQ9
XM_063272267.1 → XP_063128337.1 CLIP-associating protein 1 isoform X32

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272247.1 → XP_063128317.1 CLIP-associating protein 1 isoform X10

UniProtKB/TrEMBL

A0A8I5ZL32, F1LNQ9
XM_063272269.1 → XP_063128339.1 CLIP-associating protein 1 isoform X34

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272249.1 → XP_063128319.1 CLIP-associating protein 1 isoform X12

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272265.1 → XP_063128335.1 CLIP-associating protein 1 isoform X30

UniProtKB/TrEMBL

A0A8I5ZL32

Related

ENSRNOP00000068667.3, ENSRNOT00000084506.3
XM_063272270.1 → XP_063128340.1 CLIP-associating protein 1 isoform X35

UniProtKB/TrEMBL

A0A8I5ZL32

Related

ENSRNOP00000078541.1, ENSRNOT00000106487.2
XM_063272252.1 → XP_063128322.1 CLIP-associating protein 1 isoform X14

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272266.1 → XP_063128336.1 CLIP-associating protein 1 isoform X31

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272243.1 → XP_063128313.1 CLIP-associating protein 1 isoform X6

UniProtKB/TrEMBL

F1LNQ9
XM_063272273.1 → XP_063128343.1 CLIP-associating protein 1 isoform X38

UniProtKB/TrEMBL

F1LNR0
XM_063272246.1 → XP_063128316.1 CLIP-associating protein 1 isoform X9

UniProtKB/TrEMBL

F1LNQ9
XM_063272268.1 → XP_063128338.1 CLIP-associating protein 1 isoform X33

UniProtKB/TrEMBL

A6K7W0
XM_063272253.1 → XP_063128323.1 CLIP-associating protein 1 isoform X15

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272271.1 → XP_063128341.1 CLIP-associating protein 1 isoform X36

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272255.1 → XP_063128325.1 CLIP-associating protein 1 isoform X17

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272272.1 → XP_063128342.1 CLIP-associating protein 1 isoform X37

UniProtKB/TrEMBL

A0A8I5ZL32
XM_063272258.1 → XP_063128328.1 CLIP-associating protein 1 isoform X21

UniProtKB/TrEMBL

A0A1B0GWM1

Related

ENSRNOP00000058231.6, ENSRNOT00000061513.6