Gpr39 G protein-coupled receptor 39 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr39provided by RGD
Official Full Name: G protein-coupled receptor 39provided by RGD
Primary source: RGD:1306745
See related: EnsemblRapid:ENSRNOG00000021586 AllianceGenome:RGD:1306745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including adult feeding behavior; cellular response to zinc ion; and regulation of secretion. Predicted to be located in membrane. Orthologous to human GPR39 (G protein-coupled receptor 39). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 61.8), Kidney (RPKM 56.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (39667908..39879944)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (37115258..37327312)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (42008642..42220737)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of G protein-coupled receptor 39 alleviates neuropathic pain and chronic inflammation.
Title: Activation of G protein-coupled receptor 39 alleviates neuropathic pain and chronic inflammation.
We conclude that the orphan receptors GPR26, GPR39v1, and GPR39v2 are expressed in different tissues and their profile expression is dependent on the etiology of the Metabolic syndrome .
Title: Evidence of alterations in the expression of orphan receptors GPR26 and GPR39 due to the etiology of the metabolic syndrome.
Data suggest that changes in obestatin, GPR39, and ghrelin may contribute to metabolic abnormalities in T1DM, T2DM, and obesity.
Title: Changes in obestatin gene and GPR39 receptor expression in peripheral tissues of rat models of obesity, type 1 and type 2 diabetes.
Data suggests alterations (down-regulation) of the GPR39 receptor and involvement of CREB-BDNF pathway, possibly triggered by GPR39, as a new pathomechanism of depression
Title: The involvement of the GPR39-Zn(2+)-sensing receptor in the pathophysiology of depression. Studies in rodent models and suicide victims.
Data indicate that obestatin/GPR39 is an injury-regulated signal that functions as a myogenic regenerative system.
Title: The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative system.
These results suggest that SNARE proteins are necessary for the increased activity of KCC2 after Zn(2+) stimulation of mZnR/GPR39.
Title: SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.
GPR39 functions as a Gq-coupled Zn2+-sensing receptor
Title: Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.
GPR39-1a is expressed selectively throughout the gastrointestinal tract, including the liver and pancreas as well as in the kidney and adipose tissue, whereas truncated GPR39-1b has a broader expression pattern, including the central nervous system
Title: GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Rat20 (e-PCR)
- UniSTS:118305

BF414576 (e-PCR)
- UniSTS:248743

D13Got4 (e-PCR)
- UniSTS:114108

AU046866 (e-PCR)
- UniSTS:111062

AI853408 (e-PCR)
- UniSTS:165096

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adult feeding behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gastric emptying	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gastric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cellular pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 39

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100943.1 → NP_001094413.1 G-protein coupled receptor 39 isoform 2

See identical proteins and their annotated locations for NP_001094413.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and differs in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1. The transcript and isoform have also been referred to as GPR39-1b.

Source sequence(s)

BK005610

UniProtKB/TrEMBL

A6QR73, E9PTT1

Conserved Domains (2) summary

cd14964
Location:31 → 58

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:31 → 285

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001114392.1 → NP_001107864.1 G-protein coupled receptor 39 isoform 1

See identical proteins and their annotated locations for NP_001107864.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). The transcript and isoform have also been referred to as GPR39-1a.

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8J8Y1V6

Related

ENSRNOP00000036196.4, ENSRNOT00000038811.5

Conserved Domains (1) summary

pfam00001
Location:47 → 344

7tm_1; 7 transmembrane receptor (rhodopsin family)