Ctse cathepsin E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctseprovided by RGD
Official Full Name: cathepsin Eprovided by RGD
Primary source: RGD:2446
See related: EnsemblRapid:ENSRNOG00000006963 AllianceGenome:RGD:2446
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CEA; CEB; Ctsea
Summary: Enables aspartic-type endopeptidase activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class II and protein autoprocessing. Located in endosome. Orthologous to human CTSE (cathepsin E). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 389.2), Thymus (RPKM 338.8) and 2 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13q13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45644168..45666722)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (43091954..43114509)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (48426833..48449493)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations suggest that the overexpression of CatE interferes with neuronal differentiation of P19 cells through an impairment of cell aggregate formation, possibly through proteolytic degradation of N-cadherin.
Title: Overexpression of Cathepsin E Interferes with Neuronal Differentiation of P19 Embryonal Teratocarcinoma Cells by Degradation of N-cadherin.
The mRNA and protein expression levels of MMP-12 and Cathepsin E were significantly up-regulated in lung tissues of rats with silicotic pulmonary fibrosis.
Title: [Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats].
These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.
Title: Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.
examination of the significance of residues in the motifs of rat cathepsin E by substitution of Asp98, Asp283, and Thr284 with other residues using site-directed mutagenesis
Title: Mutational analysis of residues in two consensus motifs in the active sites of cathepsin E.
These data indicate that the catalytic activity, propeptides, and N-glycosylation of this protein are all essential for its processing, maturation, and trafficking.
Title: Characterization of rat cathepsin E and mutants with changed active-site residues and lacking propeptides and N-glycosylation, expressed in human embryonic kidney 293T cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: cathepsin E

NP_001388196.1

EC 3.4.23.34

NP_037070.2

EC 3.4.23.34

XP_006249811.1

EC 3.4.23.34

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401267.1 → NP_001388196.1 cathepsin E isoform 2 preproprotein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P16228, Q63701

UniProtKB/TrEMBL

A6IC25

Related

ENSRNOP00000048353.3, ENSRNOT00000048391.6
NM_001429468.1 → NP_001416397.1 cathepsin E isoform 2 preproprotein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P16228, Q63701

UniProtKB/TrEMBL

A6IC25
NM_012938.2 → NP_037070.2 cathepsin E isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6IC26

Related

ENSRNOP00000009242.2, ENSRNOT00000009241.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

45644168..45666722

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249749.4 → XP_006249811.1 cathepsin E isoform X1

Related

ENSRNOP00000099258.1, ENSRNOT00000124948.1

Conserved Domains (3) summary

pfam00026
Location:79 → 396

Asp; Eukaryotic aspartyl protease

pfam07966
Location:23 → 51

A1_Propeptide; A1 Propeptide

cl11403
Location:80 → 395

pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases