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    Exo1 exonuclease 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Exo1provided by RGD
    Official Full Name
    exonuclease 1provided by RGD
    Primary source
    RGD:1309465
    See related
    EnsemblRapid:ENSRNOG00000056209 AllianceGenome:RGD:1309465
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; DNA nuclease activity; and chromatin binding activity. Predicted to be involved in DNA recombination; DNA strand resection involved in replication fork processing; and mismatch repair. Predicted to act upstream of or within humoral immune response mediated by circulating immunoglobulin; isotype switching; and somatic hypermutation of immunoglobulin genes. Predicted to be located in nuclear body and plasma membrane. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 35.8), Spleen (RPKM 21.1) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Exo1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (90341947..90366861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (87809725..87834654)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (93936989..93962749)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692325 Neighboring gene ubiquitin-like modifier activating enzyme 2, pseudogene 1 Neighboring gene uncharacterized LOC134481598 Neighboring gene beclin 2 Neighboring gene phospholipase D family, member 5 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Laulederkind SJ, et al. Database (Oxford), 2011. PMID 21321022, Free PMC Article
    2. Mechanism of 5'-directed excision in human mismatch repair. Genschel J, et al. Mol Cell, 2003 Nov. PMID 14636568
    3. Molecular interactions of human Exo1 with DNA. Lee Bi BI, et al. Nucleic Acids Res, 2002 Feb 15. PMID 11842105, Free PMC Article
    4. Human exonuclease I is required for 5' and 3' mismatch repair. Genschel J, et al. J Biol Chem, 2002 Apr 12. PMID 11809771
    5. The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities. Lee BI, et al. J Biol Chem, 1999 Dec 31. PMID 10608837

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA 5'-3' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables flap endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA 5'-3' DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA strand resection involved in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exonuclease 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107198.1 → NP_001100668.1  exonuclease 1

      See identical proteins and their annotated locations for NP_001100668.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JGC0
      Related
      ENSRNOP00000073202.2, ENSRNOT00000088204.3
      Conserved Domains (2) summary
      cd09908
      Location:213 → 289
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1 → 206
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      90341947..90366861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090805.2 → XP_038946733.1  exonuclease 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4W8
      Conserved Domains (2) summary
      cd09908
      Location:213 → 289
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1 → 201
      PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

    2. XM_039090806.2 → XP_038946734.1  exonuclease 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A158
      Related
      ENSRNOP00000084933.1, ENSRNOT00000110373.2
      Conserved Domains (2) summary
      cd09908
      Location:173 → 249
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1 → 161
      PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    Nucleotide Protein Strain
    Heading Accession and Version

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