Slc30a10 solute carrier family 30, member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a10provided by RGD
Official Full Name: solute carrier family 30, member 10provided by RGD
Primary source: RGD:1305098
See related: EnsemblRapid:ENSRNOG00000002397 AllianceGenome:RGD:1305098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305098
Summary: Predicted to enable calcium:manganese antiporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including detoxification of zinc ion; intracellular monoatomic cation homeostasis; and monoatomic cation transmembrane transport. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be located in Golgi apparatus; endosome membrane; and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A10 (solute carrier family 30 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 253.1), Brain (RPKM 52.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (99529664..99584442)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (96998143..97048076)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (103396295..103406759)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter.
Title: Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547077

Slc30a10 (e-PCR), detects polymorphism
- UniSTS:547077

AW522618 (e-PCR)
- UniSTS:243452

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium:manganese antiporter activity	ISO Inferred from Sequence Orthology more info
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to angiotensin	ISO Inferred from Sequence Orthology more info
involved_in detoxification of zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular manganese ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in manganese ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in manganese ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
NOT located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium/manganese antiporter SLC30A10

Names: zinc transporter 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105985.1 → NP_001099455.1 calcium/manganese antiporter SLC30A10

See identical proteins and their annotated locations for NP_001099455.1

Status: PROVISIONAL

Source sequence(s)

CH473985

UniProtKB/TrEMBL

A6JGR9, D3ZJB7

Related

ENSRNOP00000050013.2, ENSRNOT00000049499.5

Conserved Domains (2) summary

COG1230
Location:10 → 376

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:20 → 299

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

99529664..99584442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090584.2 → XP_038946512.1 calcium/manganese antiporter SLC30A10 isoform X1

Conserved Domains (1) summary

COG1230
Location:10 → 323

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
XM_039090583.2 → XP_038946511.1 calcium/manganese antiporter SLC30A10 isoform X1

Conserved Domains (1) summary

COG1230
Location:10 → 323

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
XM_039090585.2 → XP_038946513.1 calcium/manganese antiporter SLC30A10 isoform X2

Conserved Domains (1) summary

COG1230
Location:10 → 134

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]