Rps6kc1 ribosomal protein S6 kinase C1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6kc1provided by RGD
Official Full Name: ribosomal protein S6 kinase C1provided by RGD
Primary source: RGD:1306578
See related: EnsemblRapid:ENSRNOG00000003767 AllianceGenome:RGD:1306578
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and phosphatidylinositol binding activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in endosome and lysosome. Predicted to be active in early endosome and postsynaptic density. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 57.2), Thymus (RPKM 34.6) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13q27

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (104877296..105021490, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (102346160..102491000, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (109338761..109589209, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ribosomal protein S6 kinase delta-1

Names: ribosomal protein S6 kinase, 52kDa, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1; ribosomal protein S6 kinase, polypeptide C1

NP_001402718.1

EC 2.7.11.1

NP_001402719.1

EC 2.7.11.1

XP_008768052.1

EC 2.7.11.1

XP_008768054.1

EC 2.7.11.1

XP_038946506.1

EC 2.7.11.1

XP_063128247.1

EC 2.7.11.1

XP_063128248.1

EC 2.7.11.1

XP_063128249.1

EC 2.7.11.1

XP_063128250.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001415789.1 → NP_001402718.1 ribosomal protein S6 kinase delta-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I5ZZ58
NM_001415790.1 → NP_001402719.1 ribosomal protein S6 kinase delta-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A0G2KB60, A6JGX5, D3Z991

Related

ENSRNOP00000075665.1, ENSRNOT00000087305.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

104877296..105021490 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769830.2 → XP_008768052.1 ribosomal protein S6 kinase delta-1 isoform X2

UniProtKB/TrEMBL

A6JGX5, D3Z991

Conserved Domains (5) summary

cd07287
Location:11 → 128

PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins

smart00220
Location:747 → 915

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05576
Location:738 → 915

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl00299
Location:140 → 185

MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

cl21453
Location:214 → 300

PKc_like; Protein Kinases, catalytic domain
XM_039090578.2 → XP_038946506.1 ribosomal protein S6 kinase delta-1 isoform X1

UniProtKB/TrEMBL

A6JGX5, D3Z991

Related

ENSRNOP00000085010.2, ENSRNOT00000110098.2

Conserved Domains (4) summary

cd07287
Location:11 → 128

PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins

cd02677
Location:237 → 305

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:827 → 1004

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:300 → 389

PKc_like; Protein Kinases, catalytic domain
XM_063272177.1 → XP_063128247.1 ribosomal protein S6 kinase delta-1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZZ58
XM_063272179.1 → XP_063128249.1 ribosomal protein S6 kinase delta-1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZZ58
XM_063272178.1 → XP_063128248.1 ribosomal protein S6 kinase delta-1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZZ58
XM_063272180.1 → XP_063128250.1 ribosomal protein S6 kinase delta-1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZZ58
XM_008769832.4 → XP_008768054.1 ribosomal protein S6 kinase delta-1 isoform X4

Conserved Domains (3) summary

smart00220
Location:552 → 720

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05576
Location:543 → 720

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:32 → 105

PKc_like; Protein Kinases, catalytic domain

RNA

XR_001840773.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105984.1: Suppressed sequence

Description

NM_001105984.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.