Cox18 cytochrome c oxidase assembly factor COX18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox18provided by RGD
Official Full Name: cytochrome c oxidase assembly factor COX18provided by RGD
Primary source: RGD:1559547
See related: EnsemblRapid:ENSRNOG00000003052 AllianceGenome:RGD:1559547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559547
Summary: Predicted to enable membrane insertase activity. Predicted to be involved in mitochondrial cytochrome c oxidase assembly and protein insertion into mitochondrial inner membrane from matrix. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human COX18 (cytochrome c oxidase assembly factor COX18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 29.2), Adrenal (RPKM 28.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (18147558..18161622)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (17864581..17877483)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (19434728..19446379)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables membrane insertase activity	IBA Inferred from Biological aspect of Ancestor more info
enables membrane insertase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into mitochondrial inner membrane from matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane from matrix	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into mitochondrial membrane	ISO Inferred from Sequence Orthology more info
involved_in respiratory chain complex IV assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mitochondrial inner membrane protein COX18

Names: COX18 cytochrome c oxidase assembly homolog; COX18, cytochrome c oxidase assembly factor; cytochrome c oxidase assembly homolog 18; cytochrome c oxidase assembly protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106000.1 → NP_001099470.1 mitochondrial inner membrane protein COX18

See identical proteins and their annotated locations for NP_001099470.1

Status: PROVISIONAL

Source sequence(s)

CH474060

UniProtKB/TrEMBL

A6KKG4, A6KKG5

Conserved Domains (1) summary

cl00489
Location:76 → 296

60KD_IMP; 60Kd inner membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

18147558..18161622

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250771.5 → XP_006250833.1 mitochondrial inner membrane protein COX18 isoform X1

UniProtKB/TrEMBL

A6KKG5, D4A568

Related

ENSRNOP00000004074.5, ENSRNOT00000004074.7

Conserved Domains (1) summary

cd20069
Location:76 → 297

5TM_Oxa1-like; Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins
XM_006250772.5 → XP_006250834.1 mitochondrial inner membrane protein COX18 isoform X2

Conserved Domains (1) summary

cl00489
Location:76 → 187

60KD_IMP; 60Kd inner membrane protein