Jchain joining chain of multimeric IgA and IgM [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jchainprovided by RGD
Official Full Name: joining chain of multimeric IgA and IgMprovided by RGD
Primary source: RGD:1310155
See related: EnsemblRapid:ENSRNOG00000003666 AllianceGenome:RGD:1310155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igj
Summary: Predicted to enable IgA binding activity; protein homodimerization activity; and protein-macromolecule adaptor activity. Predicted to contribute to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Predicted to be involved in several processes, including glomerular filtration; innate immune response; and positive regulation of respiratory burst. Predicted to be located in extracellular space. Predicted to be part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. Orthologous to human JCHAIN (joining chain of multimeric IgA and IgM). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (19822976..19831072)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (19538927..19547023)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (21176841..21183731)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Igj (e-PCR), detects polymorphism
- UniSTS:461922

RH133270 (e-PCR)
- UniSTS:216553

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgA binding	ISO Inferred from Sequence Orthology more info
contributes_to immunoglobulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to peptidoglycan binding	ISO Inferred from Sequence Orthology more info
contributes_to phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of dimeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
NOT part_of hexameric IgM immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of monomeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of pentameric IgM immunoglobulin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of pentameric IgM immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of secretory IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of secretory dimeric IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: immunoglobulin J chain

Names: immunoglobulin joining chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.