Tmprss11g transmembrane protease, serine 11G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmprss11gprovided by RGD
Official Full Name: transmembrane protease, serine 11Gprovided by RGD
Primary source: RGD:1306446
See related: EnsemblRapid:ENSRNOG00000029964 AllianceGenome:RGD:1306446
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Desc4; RGD1306446
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 3.4), Lung (RPKM 1.7) and 1 other tissue See more
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Genomic context

Location:: 14p21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (21901004..21942064)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (21546087..21587258)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (23166633..23207327)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The identified cleavage-sites are typical for trypsin-like serine proteases.
Title: Substrate specificity of rat DESC4, a type II transmembrane serine protease.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protease serine 11G

Names: serine protease Desc4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008554.1 → NP_001008554.1 transmembrane protease serine 11G

See identical proteins and their annotated locations for NP_001008554.1

Status: PROVISIONAL

Source sequence(s)

AJ617528

UniProtKB/Swiss-Prot

Q5NJM5, Q5QSK2

UniProtKB/TrEMBL

D3ZIU4

Related

ENSRNOP00000056857.3, ENSRNOT00000060109.5

Conserved Domains (3) summary

smart00020
Location:185 → 411

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:186 → 414

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:48 → 142

SEA; SEA domain