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    Asb3 ankyrin repeat and SOCS box-containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb3provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 3provided by RGD
    Primary source
    RGD:1308462
    See related
    EnsemblRapid:ENSRNOG00000032471 AllianceGenome:RGD:1308462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to several human genes including ASB3 (ankyrin repeat and SOCS box containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 131.7), Thymus (RPKM 116.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb3 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (108860318..108988939)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (104659406..104788032)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (115352716..115446618)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 4 Neighboring gene G protein-coupled receptor 75 Neighboring gene endoplasmic reticulum lectin 1 Neighboring gene ChaC glutathione specific gamma-glutamylcyclotransferase 2 Neighboring gene uncharacterized LOC134481883 Neighboring gene ubiquitin-conjugating enzyme E2 N-like Neighboring gene zinc finger protein 950 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 3
    Names
    ankyrin repeat and SOCS box-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108864.1 → NP_001102334.1  ankyrin repeat and SOCS box protein 3

      See identical proteins and their annotated locations for NP_001102334.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473996
      UniProtKB/TrEMBL
      A0A0G2KA67, A6JQD7, D3ZJN4
      Related
      ENSRNOP00000107365.1, ENSRNOT00000173327.1
      Conserved Domains (5) summary
      PHA02874
      Location:52 → 345
      PHA02874; ankyrin repeat protein; Provisional
      cd03722
      Location:458 → 508
      SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
      sd00045
      Location:146 → 176
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:17 → 63
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:150 → 240
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      108860318..108988939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092258.2 → XP_038948186.1  ankyrin repeat and SOCS box protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KA67, A6JQD7, D3ZJN4
      Conserved Domains (5) summary
      PHA02874
      Location:52 → 345
      PHA02874; ankyrin repeat protein; Provisional
      cd03722
      Location:458 → 508
      SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
      sd00045
      Location:146 → 176
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:17 → 63
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:150 → 240
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063273444.1 → XP_063129514.1  ankyrin repeat and SOCS box protein 3 isoform X4

      UniProtKB/TrEMBL
      D3ZJN4

    3. XM_063273443.1 → XP_063129513.1  ankyrin repeat and SOCS box protein 3 isoform X1

      UniProtKB/TrEMBL
      D3ZJN4
      Related
      ENSRNOP00000075281.3, ENSRNOT00000079169.3

    4. XM_039092261.2 → XP_038948189.1  ankyrin repeat and SOCS box protein 3 isoform X6

      Conserved Domains (3) summary
      PHA02874
      Location:32 → 299
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:157 → 187
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:161 → 251
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_039092259.2 → XP_038948187.1  ankyrin repeat and SOCS box protein 3 isoform X3

      UniProtKB/TrEMBL
      D3ZJN4
      Conserved Domains (4) summary
      PHA02874
      Location:63 → 356
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:157 → 187
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:28 → 74
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:161 → 251
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_063273445.1 → XP_063129515.1  ankyrin repeat and SOCS box protein 3 isoform X5

      UniProtKB/TrEMBL
      D3ZJN4

    7. XM_039092257.2 → XP_038948185.1  ankyrin repeat and SOCS box protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KA67, A6JQD7, D3ZJN4
      Conserved Domains (5) summary
      PHA02874
      Location:52 → 345
      PHA02874; ankyrin repeat protein; Provisional
      cd03722
      Location:458 → 508
      SOCS_ASB3; SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha ...
      sd00045
      Location:146 → 176
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:17 → 63
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:150 → 240
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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