Mob1b MOB kinase activator 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mob1bprovided by RGD
Official Full Name: MOB kinase activator 1Bprovided by RGD
Primary source: RGD:1305114
See related: EnsemblRapid:ENSRNOG00000010996 AllianceGenome:RGD:1305114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mobkl1a
Summary: Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to be involved in hippo signaling and regulation of protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB1B (MOB kinase activator 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 176.6), Kidney (RPKM 172.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (19617136..19649919, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (19333058..19365845, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (20960052..20992753, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis.
Title: Human umbilical cord mesenchymal stem cell-derived exosomes act via the miR-1263/Mob1/Hippo signaling pathway to prevent apoptosis in disuse osteoporosis.

Submit: New GeneRIF Correction

General gene information

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Markers

BE096355 (e-PCR)
- UniSTS:260545

RH133241 (e-PCR)
- UniSTS:216524

NoName (e-PCR)
- UniSTS:487894

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: MOB kinase activator 1B

Names: MOB1, Mps One Binder kinase activator-like 1A; mps one binder kinase activator-like 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.