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    Pno1 partner of NOB1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pno1provided by RGD
    Official Full Name
    partner of NOB1 homologprovided by RGD
    Primary source
    RGD:727882
    See related
    EnsemblRapid:ENSRNOG00000005524 AllianceGenome:RGD:727882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleus. Orthologous to human PNO1 (partner of NOB1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 118.2), Adrenal (RPKM 92.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pno1 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (95811335..95819903, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (91609711..91618280, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (100364192..100372760, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096673 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene protein phosphatase 3, regulatory subunit B, alpha Neighboring gene uncharacterized LOC134481791 Neighboring gene dynein axonemal assembly factor 10 Neighboring gene C1D nuclear receptor corepressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel human RNA binding protein gene PNO1. Zhou GJ, et al. DNA Seq, 2004 Jun. PMID 15497447
    2. CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. Zemp I, et al. J Cell Sci, 2014 Mar 15. PMID 24424021
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein PNO1
    Names
    putatative 28 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199083.2 → NP_954514.2  RNA-binding protein PNO1

      See identical proteins and their annotated locations for NP_954514.2

      Status: VALIDATED

      Source sequence(s)
      AI043694, AY344057
      UniProtKB/Swiss-Prot
      Q6VBQ8
      UniProtKB/TrEMBL
      A6JPZ1
      Related
      ENSRNOP00000088236.1, ENSRNOT00000110369.2
      Conserved Domains (2) summary
      smart00322
      Location:176 → 228
      KH; K homology RNA-binding domain
      COG1094
      Location:71 → 246
      Krr1; rRNA processing protein Krr1/Pno1, contains KH domain [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      95811335..95819903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6VBQ8.1 GenPept UniProtKB/Swiss-Prot:Q6VBQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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