U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ube2e1 ubiquitin-conjugating enzyme E2E 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100366017, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ube2e1provided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2E 1provided by RGD
    Primary source
    RGD:2324438
    See related
    AllianceGenome:RGD:2324438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in ISG15-protein conjugation; positive regulation of transcription by RNA polymerase II; and protein K48-linked ubiquitination. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human UBE2E1 (ubiquitin conjugating enzyme E2 E1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 128.8), Thymus (RPKM 128.1) and 9 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ube2e1 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (9870528..9924194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (7439751..7493410)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (8124869..8178252)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon AGA) 36 Neighboring gene uncharacterized LOC134482081 Neighboring gene uncharacterized protein DDB_G0290685-like Neighboring gene NFKB inhibitor interacting Ras-like 1 Neighboring gene ribosomal protein L15

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. Espinosa A, et al. Exp Cell Res, 2008 Dec 10. PMID 18845142
    2. A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells. Hu Y, et al. Biochem Biophys Res Commun, 2005 Jul 22. PMID 15936721
    3. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. Takeuchi T, et al. J Biochem, 2005 Dec. PMID 16428300
    4. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito Y, et al. Biochem J, 2006 Jun 15. PMID 16522193, Free PMC Article
    5. Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Anan T, et al. Genes Cells, 1998 Nov. PMID 9990509

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ISG15 transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ISG15 transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ISG15-protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ubiquitin-conjugating enzyme E2 E1
    NP_001386508.1
    XP_038949665.1
    XP_038949667.1
    XP_038949668.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399579.1 → NP_001386508.1  ubiquitin-conjugating enzyme E2 E1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K033, F1M3L4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      9870528..9924194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093740.2 → XP_038949668.1  ubiquitin-conjugating enzyme E2 E1 isoform X3

      Conserved Domains (1) summary
      pfam00179
      Location:14 → 151
      UQ_con; Ubiquitin-conjugating enzyme

    2. XM_039093737.2 → XP_038949665.1  ubiquitin-conjugating enzyme E2 E1 isoform X1

      Conserved Domains (2) summary
      PHA03378
      Location:19 → 108
      PHA03378; EBNA-3B; Provisional
      pfam00179
      Location:168 → 305
      UQ_con; Ubiquitin-conjugating enzyme

    3. XM_039093739.2 → XP_038949667.1  ubiquitin-conjugating enzyme E2 E1 isoform X2

      Conserved Domains (1) summary
      pfam00179
      Location:31 → 168
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.