Lcp1 lymphocyte cytosolic protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lcp1provided by RGD
Official Full Name: lymphocyte cytosolic protein 1provided by RGD
Primary source: RGD:1308288
See related: EnsemblRapid:ENSRNOG00000010319 AllianceGenome:RGD:1308288
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase binding activity; actin filament binding activity; and integrin binding activity. Involved in animal organ regeneration. Predicted to be located in several cellular components, including actin cytoskeleton; focal adhesion; and ruffle. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1086.5), Thymus (RPKM 762.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (56846375..56954090)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (50443300..50544682)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (57170566..57277811)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
Title: Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1.
the LCP1 may play a critical role in the pancreas regeneration.
Title: LCP1 up-regulated by partial pancreatectomy supports cell proliferation and differentiation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128715 (e-PCR)
- UniSTS:212023

d15mgh2 (e-PCR)
- UniSTS:120200

BI273777 (e-PCR)
- UniSTS:248823

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
NOT involved_in wound healing, spreading of cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
is_active_in actin filament bundle	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament bundle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plastin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012044.1 → NP_001012044.1 plastin-2

See identical proteins and their annotated locations for NP_001012044.1

Status: PROVISIONAL

Source sequence(s)

BC083855

UniProtKB/TrEMBL

A0A8I6AGS0, Q5XI38

Related

ENSRNOP00000014502.4, ENSRNOT00000014502.7

Conserved Domains (5) summary

smart00033
Location:398 → 501

CH; Calponin homology domain

COG5069
Location:16 → 620

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00014
Location:121 → 236

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:13 → 79

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:265 → 370

CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

56846375..56954090

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274316.1 → XP_063130386.1 plastin-2 isoform X1

UniProtKB/TrEMBL

A0A8I6AGS0, Q5XI38

Related

ENSRNOP00000071263.2, ENSRNOT00000082191.3
XM_006252319.3 → XP_006252381.1 plastin-2 isoform X1

See identical proteins and their annotated locations for XP_006252381.1

UniProtKB/TrEMBL

A0A8I6AGS0, Q5XI38

Conserved Domains (5) summary

smart00033
Location:398 → 501

CH; Calponin homology domain

COG5069
Location:16 → 620

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00014
Location:121 → 236

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:13 → 79

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00307
Location:265 → 370

CH; Calponin homology (CH) domain