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    Kctd6 potassium channel tetramerization domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kctd6provided by RGD
    Official Full Name
    potassium channel tetramerization domain containing 6provided by RGD
    Primary source
    RGD:1308208
    See related
    EnsemblRapid:ENSRNOG00000007817 AllianceGenome:RGD:1308208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ankyrin binding activity; cullin family protein binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Orthologous to human KCTD6 (potassium channel tetramerization domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 63.2), Liver (RPKM 42.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd6 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19125529..19142038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16695297..16712460, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18484607..18493188, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096930 Neighboring gene acyl-CoA oxidase 2 Neighboring gene heat shock protein family E (Hsp10) member 1, pseudogene 2 Neighboring gene pyruvate dehydrogenase E1 subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. De Smaele E, et al. Neoplasia, 2011 Apr. PMID 21472142, Free PMC Article
    2. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Lange S, et al. Mol Biol Cell, 2012 Jul. PMID 22573887, Free PMC Article
    3. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. Smaldone G, et al. FEBS Lett, 2016 Jun. PMID 27152988
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ankyrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD6
    Names
    potassium channel tetramerisation domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107253.2 → NP_001100723.1  BTB/POZ domain-containing protein KCTD6 isoform 1

      See identical proteins and their annotated locations for NP_001100723.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K0B5, B0BNF4, G3V6Z2
      Related
      ENSRNOP00000010303.4, ENSRNOT00000010303.7
      Conserved Domains (1) summary
      cd18394
      Location:10 → 113
      BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

    2. NM_001431403.1 → NP_001418332.1  BTB/POZ domain-containing protein KCTD6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K0B5, B0BNF4, G3V6Z2

    3. NM_001431404.1 → NP_001418333.1  BTB/POZ domain-containing protein KCTD6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      B0BNF4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      19125529..19142038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093246.2 → XP_038949174.1  BTB/POZ domain-containing protein KCTD6 isoform X1

      UniProtKB/TrEMBL
      A6K0B5, B0BNF4, G3V6Z2
      Conserved Domains (1) summary
      cd18394
      Location:10 → 113
      BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

    2. XM_039093245.2 → XP_038949173.1  BTB/POZ domain-containing protein KCTD6 isoform X1

      Related
      ENSRNOP00000101082.1, ENSRNOT00000165981.1
      Conserved Domains (1) summary
      cd18394
      Location:10 → 113
      BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

    3. XM_006251763.5 → XP_006251825.1  BTB/POZ domain-containing protein KCTD6 isoform X1

      Conserved Domains (1) summary
      cd18394
      Location:10 → 113
      BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)

    4. XM_039093249.2 → XP_038949177.1  BTB/POZ domain-containing protein KCTD6 isoform X1

      UniProtKB/TrEMBL
      A6K0B5, B0BNF4, G3V6Z2
      Conserved Domains (1) summary
      cd18394
      Location:10 → 113
      BTB_POZ_KCTD6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6)
    Nucleotide Protein Strain
    Heading Accession and Version

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