Cysltr2 cysteinyl leukotriene receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cysltr2provided by RGD
Official Full Name: cysteinyl leukotriene receptor 2provided by RGD
Primary source: RGD:619797
See related: EnsemblRapid:ENSRNOG00000067464 AllianceGenome:RGD:619797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyslt2; RSBPT32
Summary: Predicted to enable G protein-coupled peptide receptor activity and cysteinyl leukotriene receptor activity. Involved in several processes, including cellular response to hypoxia; negative regulation of glial cell proliferation; and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl leukotriene receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 57.3), Lung (RPKM 32.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (54599043..54638314, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (48189476..48228750, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (54903290..54941742, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The spatiotemporal profiles of CysLT2 receptor expression suggest that it plays regulatory roles in acute neuron injury, and astrocytosis and microgliosis in the late phase.
Title: Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteinyl leukotriene receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteinyl leukotriene receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in leukotriene signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteinyl leukotriene receptor 2

Names: cysteinyl leukotriene CysLT2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133413.2 → NP_596904.1 cysteinyl leukotriene receptor 2

See identical proteins and their annotated locations for NP_596904.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q924T9

Related

ENSRNOP00000087467.1, ENSRNOT00000115019.2

Conserved Domains (2) summary

cd14964
Location:24 → 50

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:24 → 300

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily